Potential Role of Circulating PD-L1+ Leukocytes as a Predictor of Response to Anti-PD-(L)1 Therapy in NSCLC Patients
Anguera, Georgia ![Identificador ORCID](/img/uab/orcid.ico)
(Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Mulet Gual, Maria ![Identificador ORCID](/img/uab/orcid.ico)
(Institut de Recerca Sant Pau)
Zamora, Carlos ![Identificador ORCID](/img/uab/orcid.ico)
(Institut de Recerca Sant Pau)
Osuna Gómez, Rubén ![Identificador ORCID](/img/uab/orcid.ico)
(Institut de Recerca Sant Pau)
Barba Joaquin, Andrés ![Identificador ORCID](/img/uab/orcid.ico)
(Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Sullivan, Ivana ![Identificador ORCID](/img/uab/orcid.ico)
(Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Serra, Jorgina
(Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Cantó, Elisabet
(Institut de Recerca Sant Pau)
Vidal, Silvia
(Institut de Recerca Sant Pau)
Majem, Margarita
(Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Universitat Autònoma de Barcelona
Data: |
2024 |
Resum: |
PD-(L)1 inhibitors are part of the treatment strategy for non-small cell lung cancer (NSCLC) although its efficacy is limited to certain patients. Our study aimed to identify patients who might benefit from anti-PD-(L)1 inhibitors by analyzing the PD-L1 expression on circulating leukocytes and its evolution during treatment. One hundred thirteen NSCLC patients, according to their radiological response after 10-12 weeks of treatment, were classified into responders, stable, and progressive disease. Percentages of circulating PD-L1 leukocytes, PD-L1 platelets (PLTs), and leukocyte-PLT complexes were assessed using flow cytometry, and plasma concentrations of soluble immunomodulatory factors were quantified by ELISA. Responders exhibited significantly higher pre-treatment percentages of PD-L1 neutrophils, PD-L1 CD14 cells, and PD-L1 PLTs than progressors. The percentages of these populations decreased in responders post-treatment, contrasting with stables and progressors. PLTs notably contributed to PD-L1 expression in CD14 cells and neutrophils. Plasma cytokine analysis revealed baseline differences only in IL-17 concentration among groups, whereas network analyses highlighted distinct association patterns between plasma molecules and PD-L1 leukocytes after 10-12 weeks of treatment. Our findings suggest that pre-treatment assessment of circulating PD-L1 neutrophils, PD-L1 CD14 cells, and PD-L1 PLTs may be helpful in identifying NSCLC patients who are potential candidates for anti-PD-(L)1 therapy. |
Drets: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ![Creative Commons](/img/licenses/by.ico) |
Llengua: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Matèria: |
NSCLC ;
PD-L1+ CD14+ cells ;
PD-L1+ neutrophils ;
PDL-1+ platelets ;
Immunotherapy |
Publicat a: |
Biomedicines, Vol. 12 Núm. 5 (may 2024) , p. 958, ISSN 2227-9059 |
DOI: 10.3390/biomedicines12050958
PMID: 38790920
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Registre creat el 2024-06-04, darrera modificació el 2024-06-08