Gold and titania nanoparticles accumulated in the body induce late toxic effects and alterations in transcriptional and miRNA landscape
Soltysova, Andrea (Slovak Academy of Sciences)
Ludwig, Nicole (Saarland University)
Diener, Caroline (Saarland University)
Sramkova, Monika (Slovak Academy of Sciences. Department of Nanobiology)
Kozics, Katarina (Slovak Academy of Sciences. Department of Nanobiology)
Jakic, Kristina (Slovak Academy of Sciences. Department of Nanobiology)
Balintova, Lucia (Slovak Academy of Sciences. Department of Nanobiology)
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia)
Moriones, Oscar Hernando (Institut Català de Nanociència i Nanotecnologia)
Liskova, Aurelia (Slovak Medical University in Bratislava)
Krivosikova, Zora (Slovak Medical University in Bratislava)
Rollerova, Eva (Slovak Medical Univerity in Bratislava. Department of Toxicology)
Manova, Alena (Slovak University of Technology in Bratislava)
Dubaj, Tibor (Slovak University of Technology in Bratislava)
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Šimon, Peter (Slovak University of Technology in Bratislava)
Wsolova, Ladislava (Slovak Medical University in Bratislava)
Tulinska, Jana (Slovak Medical University in Bratislava)
Smolkova, Bozena (Slovak Academy of Sciences. Department of Molecular Oncology)
Meese, Eckart (Saarland University)
Gabelova, Alena (Slovak Academy of Sciences. Department of Nanobiology)

Data:	2024
Resum:	The growing production of nanomaterials and their presence in consumer products raises fear about their impact on human health and the environment. Of particular concern are those nanomaterials that exhibit poor excretion and tend to accumulate in living organisms. Our study investigated the potential adverse biological effects of residual gold and titania nanoparticles (PEG-AuNPs and TiONPs) 28 days after a single intravenous administration in rats. To comprehensively assess the potential health hazard of these metal nanoparticles (MNP), toxicological and transcriptomic analyses were employed. The liver was the primary organ of the MNP deposition, causing a reduction in the relative liver weight compared to unexposed animals. Concurrently, changes in serum biomarkers indicative of hepatic dysfunction and hematological and immunological alternations were determined. Integrated transcriptomic analysis unveiled exposure-induced effects on the rats' lungs, liver, and kidneys. The hepatic tissue, particularly in PEG-AuNPs-exposed rats, exhibited a noteworthy prevalence of deregulated genes, with functional classification spanning lipid metabolism, cell cycle, and cell proliferation pathways. Although the number of deregulated miRNAs was relatively modest compared to mRNA expression changes, both types of MNPs deregulated miR-203a, associated with liver injury, and miR-18a-5p and miR-32-5p linked to kidney damage. This study underscores the imperative for a more exhaustive biosafety assessment of poorly soluble MNPs that tend to deposit in the body. Such investigations are crucial for delineating the potential risks of these nanomaterials and guiding the development of adequate safety measures in their production and usage.
Ajuts:	European Commission 685817 European Commission 857381
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Biological effects ; Growing production ; Human health ; Intravenous administration ; Living organisms ; Residual gold ; TiO 2 ; Titania ; Toxic effect ; Transcriptomics
Publicat a:	Environmental science. Nano, Vol. 11, Issue 3 (March 2024) , p. 1296-1313, ISSN 2051-8161

DOI: 10.1039/d3en00954h

18 p, 1.9 MB

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