Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents : A Comprehensive Review
Parisi, Mónica G. (Universidad Nacional de Luján. Departamento de Ciencias Básicas)
Ozón, Brenda (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas)
Vera González, Sofía M. (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas)
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Obregón, Walter David (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas)
Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular

Date:	2024
Abstract:	Antimicrobial peptides (AMPs) are important mediator molecules of the innate defense mechanisms in a wide range of living organisms, including bacteria, mammals, and plants. Among them, peptide protease inhibitors (PPIs) from plants play a central role in their defense mechanisms by directly attacking pathogens or by modulating the plant's defense response. The growing prevalence of microbial resistance to currently available antibiotics has intensified the interest concerning these molecules as novel antimicrobial agents. In this scenario, PPIs isolated from a variety of plants have shown potential in inhibiting the growth of pathogenic bacteria, protozoans, and fungal strains, either by interfering with essential biochemical or physiological processes or by altering the permeability of biological membranes of invading organisms. Moreover, these molecules are active inhibitors of a range of proteases, including aspartic, serine, and cysteine types, with some showing particular efficacy as trypsin and chymotrypsin inhibitors. In this review, we provide a comprehensive analysis of the potential of plant-derived PPIs as novel antimicrobial molecules, highlighting their broad-spectrum antimicrobial efficacy, specificity, and minimal toxicity. These natural compounds exhibit diverse mechanisms of action and often multifunctionality, positioning them as promising molecular scaffolds for developing new therapeutic antibacterial agents.
Grants:	Ministerio de Ciencia e Innovación IJC2019-041039-I)
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Plant protease inhibitors ; Antibacterial compounds ; Antimicrobial activity ; Antimicrobial peptides ; Antibiotic resistance ; Antifungal agents ; Cysteine-rich peptides
Published in:	Pharmaceutics, Vol. 16, Issue 5 (May 2024) , art. 582, ISSN 1999-4923

DOI: 10.3390/pharmaceutics16050582
PMID: 38794245

15 p, 1.6 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles