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| Pàgina inicial > Articles > Articles publicats > Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex |
(Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Universidad de Málaga. Facultad de Psicología) (Instituto de Investigación Biomédica de Málaga) (Instituto de Investigación Biomédica de Málaga) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Centro Provincial de Drogodependencias de Málaga) (Instituto de Investigación Biomédica de Málaga) (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
| Data: | 2022 |
| Resum: | (1) Background: Co-occurrence of mental and substance use disorders (SUD) is prevalent, but complicates their clinical courses, and specific biomarkers are required. Amino acids are altered in primary mental disorders; however, little is known about SUD and psychiatric comorbidity. Because most psychiatric disorders and biomarkers show sex differences, we investigated amino acids in men and women with alcohol and/or cocaine use disorders (AUD and/or CUD) and psychiatric comorbidity. (2) Methods: A cross-sectional study was conducted in 295 participants, who were divided into four groups (AUD, n = 60; CUD, n = 41; AUD + CUD, n = 64; and control, n = 130). Participants were clinically assessed, and plasma amino acid concentrations were analyzed in relation to sex, diagnosis of SUD and psychiatric comorbidity (3) Results: In the total sample, there were sex differences, and women showed lower Iso, Leu, Gln and Glu than men. While patients with CUD and AUD + CUD had higher Glu, Gly, Orn and Ser than controls, patients with AUD showed no differences. In SUD, patients with psychiatric comorbidity had lower Orn and higher Ala than non-comorbid patients in the AUD group. (4) Conclusions: There was a dysregulation of plasma amino acids in abstinent patients with SUD. However, our results suggest the importance of considering the clinical characteristics and sex in the validity of amino acids as potential biomarkers for SUD. |
| Ajuts: | Ministerio de Economía y Competitividad RD16/0017/0001 Ministerio de Economía y Competitividad RD16/0017/0022 Instituto de Salud Carlos III PI19/01577 Instituto de Salud Carlos III PI20/01399 Agencia Estatal de Investigación PID2019-111594RB-I00 Instituto de Salud Carlos III CD19/00019 Instituto de Salud Carlos III CPII19/00022 Instituto de Salud Carlos III CPII19/00031 |
| Nota: | Catedres |
| Nota: | Altres ajuts: Proyectos de Investigación en Drogodependencias (2016I073,2017I043, 2018I033, 2018I044 and 2021I043) funded by Delegación del Gobierno para el Plan Nacional sobre Drogas, Ministerio de Sanidad and ERDF/ESF; ; Proyectos de Investigación en Salud (PI-0140-2018) funded by Consejería de Salud y Familias, Junta de Andalucía and ERDF/ES; Proyectos I+D+I en el marco del Programa Operativo FEDER Andalucía 2014-2020 (UMA18-FEDERJA-059) funded by Consejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía and ERDF/ESF. |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Abstinence ; Alcohol use disorder ; Amino acids ; Biomarker ; CE-LIF ; Cocaine use disorder ; Cross-sectional study; ; PRISM ; Psychiatric comorbidity ; Sex |
| Publicat a: | Biomedicines, Vol. 10 Núm. 5 (may 2022) , ISSN 2227-9059 |
