DCTclock : Clinically-Interpretable and Automated Artificial Intelligence Analysis of Drawing Behavior for Capturing Cognition
Souillard-Mandar, William (Massachusetts Institute of Technology (Estats Units d'Amèrica))
Penney, Dana (Department of Neurology, Lahey Hospital and Medical Center (Estats Units d'Amèrica))
Schaible, Braydon (Digital Cognition Technologies (Boston, Estats Units d'Amèrica))
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann)
Au, Rhoda (Boston University School of Medicine)
Davis, Randall (Massachusetts Institute of Technology (Estats Units d'Amèrica))
Universitat Autònoma de Barcelona

Data:	2021
Resum:	Developing tools for efficiently measuring cognitive change specifically and brain health generally-whether for clinical use or as endpoints in clinical trials-is a major challenge, particularly for conditions such as Alzheimer's disease. Technology such as connected devices and advances in artificial intelligence offer the possibility of creating and deploying clinical-grade tools with high sensitivity, rapidly, cheaply, and non-intrusively. Starting from a widely-used paper and pencil cognitive status test-The Clock Drawing Test-we combined a digital input device to capture time-stamped drawing coordinates with a machine learning analysis of drawing behavior to create DCTclock™, an automated analysis of nuances in cognitive performance beyond successful task completion. Development and validation was conducted on a dataset of 1,833 presumed cognitively unimpaired and clinically diagnosed cognitively impaired individuals with varied neurological conditions. We benchmarked DCTclock against existing clock scoring systems and the Mini-Mental Status Examination, a widely-used but lengthier cognitive test, and showed that DCTclock offered a significant improvement in the detection of early cognitive impairment and the ability to characterize individuals along the Alzheimer's disease trajectory. This offers an example of a robust framework for creating digital biomarkers that can be used clinically and in research for assessing neurological function.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Artificial intelligence ; Cognition ; Alzheimer's disease ; Dementia ; DCTclock ; Clock drawing test ; Behavior analysis
Publicat a:	Frontiers in Digital Health, Vol. 3 (october 2021) , ISSN 2673-253X

DOI: 10.3389/fdgth.2021.750661
PMID: 34723243

10 p, 804.4 KB

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