Disposition of Work-Related Asthma in a Spanish Asthma Cohort : Comparison of Asthma Severity Between Employed and Retired Workers
Romero Mesones, Christian (Universitat Autònoma de Barcelona. Departament de Medicina)
Cruz Carmona, María Jesús (Hospital Universitari Vall d'Hebron)
Alobid, Isam (Hospital Clínic i Provincial de Barcelona)
Barroso, Blanca (Hospital Universitario Fundación Jiménez Díaz)
Arismendi, Ebymar (Hospital Clínic i Provincial de Barcelona)
Barranco, Pilar (Hospital Universitario La Paz (España))
Betancor, Diana (Hospital Universitario Fundación Jiménez Díaz)
Bobolea, Irina (Hospital Clínic i Provincial de Barcelona)
Cárdaba, Blanca (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Curto, Elena (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Domènech Casadevall, Gemma (Hospital Clínic i Provincial de Barcelona)
Domínguez-Ortega, Javier (Hospital Universitario La Paz (Madrid))
Espejo, David (Hospital Universitari Vall d'Hebron)
González-Barcala, Francisco-Javier (Complejo Hospitalario Universitario de Santiago de Compostela)
Luna-Porta, Juan-Alberto (Hospital Universitario La Paz (España))
Martínez Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Méndez-Brea, Paula (Complejo Hospitalario Universitario de Santiago)
Mullol, Joaquim (Universitat de Barcelona)
Olaguibel, Jose-Maria (Complejo Hospitalario de Navarra)
Picado, Cesar (Instituto de Investigaciones Biomédicas August Pi i Sunyer)
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau)
del Pozo, Victoria (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Quirce, Santiago (Hospital Universitario La Paz (España))
Rial, Manuel-Jorge (Complexo Hospitalario Universitario)
Rodrigo-Muñoz, José María (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Sastre, Joaquin (Hospital Universitario Fundación Jiménez Díaz)
Serrano, Sandra (Hospital Clínic i Provincial de Barcelona)
Soto-Retes, Lorena (Institut d'Investigació Biomèdica Sant Pau)
Valero, Antonio (Hospital Clínic i Provincial de Barcelona)
Valverde-Monge, Marcela (Hospital Universitario Fundación Jiménez Díaz)
Muñoz Gall, Xavier (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Exposure to certain agents in the workplace can trigger occupational asthma or work-exacerbated asthma, both of which come under the heading of work-related asthma (WRA). Understanding the burden that WRA represents can help in the management of these patients. To assess the influence of occupation on asthma in real life and analyze the characteristics of patients with WRA included in an asthma cohort. This was a prospective multicenter study of a cohort of consecutive patients with asthma. A standardized clinical history was completed. Patients were classified as having WRA or non-WRA. All patients underwent respiratory function tests, FeNO test, and methacholine challenge (methacholine concentration that causes a 20% drop in FEV) at the beginning of the study. They were classified into two groups, depending on their employment status: employed (group 1) or unemployed (group 2). Of the 480 patients included in the cohort, 82 (17%) received the diagnosis of WRA. Fifty-seven patients (70%) were still working. Mean age (SD) was 46 (10. 69) years in group 1 and 57 (9. 91) years in group 2 (P <. 0001). Significant differences were observed in adherence to treatment (64. 9% in group 1 vs 88% in group 2; P =. 0354) and in severe asthma exacerbations (35. 7% in group 1 vs 0% in group 2; P =. 0172). No significant differences were observed in the rest of the variables analyzed. The burden of WRA in specialized asthma units is not negligible. The absence of differences in the severity of asthma, the treatment administered, alterations in lung function, and the number of exacerbations in those working versus not working may support the idea that advice regarding changing jobs should be customized for individual patients.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Exacerbation ; Occupational asthma ; Work-exacerbated asthma
Published in:	Journal of Allergy and Clinical Immunology: In Practice, Vol. 11 Núm. 11 (november 2023) , p. 3407-3413.e1, ISSN 2213-2198

DOI: 10.1016/j.jaip.2023.06.040
PMID: 37391017

8 p, 256.2 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles