Disease and Economic Burden of Poor Metabolic and Weight Control in Type 2 Diabetes in Spain : A Systematic Literature Review
Pérez Pérez, Antonio (Institut de Recerca Sant Pau)
Redondo-Antón, J. (Eli Lilly and Company)
Romera, I. (Eli Lilly and Company)
Lizán, L. (Universitat Jaume I)
Rubio-de Santos, M. (Eli Lilly and Company)
Díaz-Cerezo, Silvia (Eli Lilly and Company)
Orozco-Beltrán, D. (Universidad Miguel Hernández de Elche)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Poor metabolic control and excess body weight are frequently present in people with type 2 diabetes (PwT2D). A systematic literature review was conducted to identify observational studies reporting clinical, economic, and health-related quality of life (HRQoL) outcomes associated with poor metabolic (according to HbA1c, blood pressure [BP] and low density lipoprotein cholesterol [LDL-C] levels) and/or weight control (defined by a body mass index [BMI] ≥ 30 kg/m) in adults with T2D in Spain, including articles published in either Spanish or English between 2013 and 2022 and conference abstracts from the last 2 years. Nine observational studies were included in the analysis. Poor glycemic control (HbA1c ≥ 7%) was associated with cardiovascular disease (CVD), increased requirements for antidiabetic medications, higher and more frequent weight gain, a greater probability of hypoglycemia and dyslipidemia, and worse health-related quality of life (HRQoL). Uncontrolled BP in PwT2D was related with the presence of CVD, worse metabolic control, and higher BMI and abdominal perimeter values. Poor LDL-C control or dyslipidemia was associated with CVD, hypoglycemia, and elevated HbA1c and triglycerides levels. The presence of a BMI ≥ 30 kg/m was related to CVD and hypoglycemia, a higher prevalence of metabolic syndrome and worse BP control. Direct medical costs were found to be higher in PwT2D when coexisting with HbA1c levels ≥ 7%, uncontrolled BP or obesity. Increased total costs, including productivity losses, were also detected in those who presented uncontrolled BP and a BMI ≥ 30 kg/m, and when poor weight control existed together with HbA1c ≥ 8% and poorly controlled BP. Gathered evidence supports the high clinical, economic and HRQoL burden of poor metabolic and/or weight control in PwT2D in Spain and reinforces the importance of prioritizing its control to reduce the associated burden, at both the individual and healthcare system levels.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Matèria:	Burden of illness ; HbA1c ; Obesity ; Type 2 diabetes mellitus
Publicat a:	Diabetes Therapy, Vol. 15 Núm. 2 (february 2024) , p. 325-341, ISSN 1869-6961

DOI: 10.1007/s13300-023-01503-4
PMID: 37989829

17 p, 1.2 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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