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| Pàgina inicial > Articles > Articles publicats > The early-life exposome and epigenetic age acceleration in children |
(Institut de Salut Global de Barcelona) (Universitat Pompeu Fabra) (Vytautas Magnus University. Department of Environmental Sciences) (Instituto de Investigación Sanitaria de Santiago (IDIS)) (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) (Vytautas Magnus University. Department of Environmental Sciences) (Norwegian Institute of Public Health. Department of Environmental Health) (Centre National de la Recherche Scientifique. Université de Grenoble Alpes) (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) (Imperial College London. Centre for Environment and Health) (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) (Institut de Salut Global de Barcelona)
| Data: | 2021 |
| Resum: | The early-life exposome influences future health and accelerated biological aging has been proposed as one of the underlying biological mechanisms. We investigated the association between more than 100 exposures assessed during pregnancy and in childhood (including indoor and outdoor air pollutants, built environment, green environments, tobacco smoking, lifestyle exposures, and biomarkers of chemical pollutants), and epigenetic age acceleration in 1,173 children aged 7 years old from the Human Early-Life Exposome project. Age acceleration was calculated based on Horvath's Skin and Blood clock using child blood DNA methylation measured by Infinium HumanMethylation450 BeadChips. We performed an exposure-wide association study between prenatal and childhood exposome and age acceleration. Maternal tobacco smoking during pregnancy was nominally associated with increased age acceleration. For childhood exposures, indoor particulate matter absorbance (PMabs) and parental smoking were nominally associated with an increase in age acceleration. Exposure to the organic pesticide dimethyl dithiophosphate and the persistent pollutant polychlorinated biphenyl-138 (inversely associated with child body mass index) were protective for age acceleration. None of the associations remained significant after multiple-testing correction. Pregnancy and childhood exposure to tobacco smoke and childhood exposure to indoor PMabs may accelerate epigenetic aging from an early age. |
| Ajuts: | European Commission 308333 European Commission 874583 European Commission 733206 European Commission 211250 European Commission 226285 Ministerio de Ciencia e Innovación CEX2018-000806-S Generalitat de Catalunya FI-DGR 2015 Generalitat de Catalunya 016FI_B 00272 Instituto de Salud Carlos III CD12/00563 Instituto de Salud Carlos III MS16/00128 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Aging ; Childhood ; Environmental exposures ; Epigenetic age acceleration ; Pregnancy ; SDG 3 - Good Health and Well-being |
| Publicat a: | Environment International, Vol. 155 (October 2021) , art. 106683, ISSN 1873-6750 |
