Cross-Validation of Risk Scores for Patients Undergoing Transcatheter Edge-to-Edge Repair for Mitral Regurgitation
Estevez-Loureiro, Rodrigo (Hospital Álvaro Cunqueiro (Vigo))
Shah, Neeraj (East Carolina University)
Raposeiras-Roubin, Sergio (Hospital Álvaro Cunqueiro (Vigo))
Kotinkaduwa, Lak N. (Cardiovascular Research Foundation)
Madhavan, Mahesh V. (NewYork-Presbyterian Hospital)
Gray, William A. (Lankenau Heart Institute)
Lindenfeld, JoAnn (Vanderbilt Heart and Vascular Institute)
Adamo, Marianna (University of Brescia)
Abraham, William T. (The Ohio State University Wexner Medical Center)
Freixa, Xavier (Hospital Clínic i Provincial de Barcelona)
Grayburn, Paul A. (Baylor Scott & White Heart and Vascular Hospitals)
Arzamendi, Dabit (Institut de Recerca Sant Pau)
Kar, Saibal (Bakersfield Heart Hospital)
Benito-González, Tomás (Hospital Universitario de León)
Lim, D.Scott (University of Virginia Health System)
Montefusco, Antonio (University of Turin)
Redfors, Björn (University of Gothenburg)
Pascual, Isaac (Hospital Universitario Central de Asturias)
Nombela-Franco, Luís (Hospital Clínico San Carlos (Madrid))
Rodes-Cabau, Josep (Laval University)
Shuvy, Mony (Heart Institute Hadassah-Hebrew University Medical Center)
Moñivas, Vanessa (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Godino, Cosmo (IRCCS San Raffaele Scientific Institute (Milà, Itàlia))
Mack, Michael J. (Baylor Scott & White Health)
Bedogni, Francesco (IRCCS Policlinico San Donato (Itàlia))
Stone, Gregg W. (The Zena and Michael A. Wiener Cardiovascular Institute)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Background: Risk scores may identify patients with mitral regurgitation (MR) who are at risk for adverse events, but who may still benefit from transcatheter edge-to-edge repair (TEER). We sought to cross-validate the MitraScore and COAPT risk score to predict adverse events in patients undergoing TEER. Methods: MitraScore validation was carried out in the COAPT population which included 614 patients with FMR who were randomized 1:1 to guideline-directed medical therapy (GDMT) with or without TEER and were followed for 2 years. Validation of the COAPT risk score was carried out in 1007 patients from the MIVNUT registry of TEER-treated patients with both FMR and degenerative MR who were followed for a mean of 2. 1 years. The predictive value was assessed using the area under the receiver operating characteristic curve (AUC) plots. The primary outcome was all-cause mortality. Results: The MitraScore had fair to good predictive accuracy for mortality in the overall COAPT trial population (AUC, 0. 67); its accuracy was higher in patients treated with TEER (AUC, 0. 74) than GDMT alone (AUC, 0. 65). The COAPT risk score had fair predictive accuracy for death in the overall MitraScore cohort (AUC, 0. 64), which was similar in patients with FMR and degenerative MR (AUC, 0. 64 and 0. 66, respectively). There was a consistent benefit of treatment with TEER plus GDMT compared with GDMT alone in the COAPT trial population across all MitraScore risk strata. Conclusions: The COAPT risk score and MitraScore are simple tools that are useful for the prediction of 2-year mortality in patients eligible for or undergoing treatment with TEER.
Nota:	Altres ajuts: The COAPT trial was sponsored by Abbott. ClinicalTrials.gov number, NCT01626079.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	COAPT ; MitraScore ; Mitral regurgitation ; Mortality ; Risk score ; Transcatheter edge-to-edge repair
Publicat a:	Journal of the Society for Cardiovascular Angiography and Interventions, Vol. 3 Núm. 2 (february 2024) , p. 101227, ISSN 2772-9303

DOI: 10.1016/j.jscai.2023.101227
PMID: 39132211

10 p, 2.3 MB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
Articles > Articles de recerca
Articles > Articles publicats