Evidence-informed recommendations to reduce dissemination bias in clinical research : Conclusions from the OPEN (Overcome failure to Publish nEgative fiNdings) project based on an international consensus meeting
Meerpohl, Joerg J. (University of Freiburg (Alemanya))
Schell, Lisa K. (University of Freiburg (Alemanya))
Bassler, Dirk (University Hospital of Tübingen (Alemanya))
Gallus, Silvano (IRCCS Istituto Giannina Gaslini (Gènova, Itàlia))
Kleijnen, Jos (Maastricht University (Països Baixos))
Kulig, Michael (Gemeinsamer Bundesausschuss (Alemanya))
La Vecchia, Carlo (University of Milan (Milà, Itàlia))
Marušić, Ana (University of Split School of Medicine (Croàcia))
Ravaud, Philippe (Paris Descartes University (França))
Reis, Andreas (World Health Organization (Suïssa))
Schmucker, Christine (University of Freiburg (Alemanya))
Strech, Daniel (Hannover Medical School)
Urrútia, Gerard (Institut d'Investigació Biomèdica Sant Pau)
Wager, Elizabeth (Sideview (Regne Unit))
Antes, Gerd (University of Freiburg (Alemanya))
Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública

Data:	2015
Resum:	Background: Dissemination bias in clinical research severely impedes informed decision-making not only for healthcare professionals and patients, but also for funders, research ethics committees, regulatory bodies and other stakeholder groups that make health-related decisions. Decisions based on incomplete and biased evidence cannot only harm people, but may also have huge financial implications by wasting resources on ineffective or harmful diagnostic and therapeutic measures, and unnecessary research. Owing to involvement of multiple stakeholders, it remains easy for any single group to assign responsibility for resolving the problem to others. Objective: To develop evidence-informed general and targeted recommendations addressing the various stakeholders involved in knowledge generation and dissemination to help overcome the problem of dissemination bias on the basis of previously collated evidence. Methods: Based on findings from systematic reviews, document analyses and surveys, we developed general and targeted draft recommendations. During a 2-day workshop in summer 2013, these draft recommendations were discussed with external experts and key stakeholders, and refined following a rigorous and transparent methodological approach. Results: Four general, overarching recommendations applicable to all or most stakeholder groups were formulated, addressing (1) awareness raising, (2) implementation of targeted recommendations, (3) trial registration and results posting, and (4) systematic approaches to evidence synthesis. These general recommendations are complemented and specified by 47 targeted recommendations tailored towards funding agencies, pharmaceutical and device companies, research institutions, researchers (systematic reviewers and trialists), research ethics committees, trial registries, journal editors and publishers, regulatory agencies, benefit (health technology) assessment institutions and legislators. Conclusions: Despite various recent examples of dissemination bias and several initiatives to reduce it, the problem of dissemination bias has not been resolved. Tailored recommendations based on a comprehensive approach will hopefully help increase transparency in biomedical research by overcoming the failure to disseminate negative findings.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Bias (Epidemiology) ; Biomedical Research ; Consensus ; Decision Making ; Evidence-Based Medicine ; Humans ; Publishing ; Technology Assessment, Biomedical
Publicat a:	BMJ open, Vol. 5 Núm. 5 (2015) , p. e006666, ISSN 2044-6055

DOI: 10.1136/bmjopen-2014-006666
PMID: 25943371

9 p, 810.3 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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