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Página principal > Artículos > Artículos publicados > CSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer's disease |
Fecha: | 2023 |
Resumen: | Diagnosis of dementia with Lewy bodies (DLB) is challenging and specific biofluid biomarkers are highly needed. We employed proximity extension-based assays to measure 665 proteins in the cerebrospinal fluid (CSF) from patients with DLB (n = 109), Alzheimer's disease (AD, n = 235) and cognitively unimpaired controls (n = 190). We identified over 50 CSF proteins dysregulated in DLB, enriched in myelination processes among others. The dopamine biosynthesis enzyme DDC was the strongest dysregulated protein, and could efficiently discriminate DLB from controls and AD (AUC:0. 91 and 0. 81 respectively). Classification modeling unveiled a 7-CSF biomarker panel that better discriminate DLB from AD (AUC:0. 93). A custom multiplex panel for six of these markers (DDC, CRH, MMP-3, ABL1, MMP-10, THOP1) was developed and validated in independent cohorts, including an AD and DLB autopsy cohort. This DLB CSF proteome study identifies DLB-specific protein changes and translates these findings to a practicable biomarker panel that accurately identifies DLB patients, providing promising diagnostic and clinical trial testing opportunities. |
Ayudas: | Instituto de Salud Carlos III PI18/00435 Instituto de Salud Carlos III PI20/01330 Agencia Estatal de Investigación PID2020-115613RA-I00 |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Alzheimer Disease ; Autopsy ; Biomarkers ; Humans ; Lewy Body Disease ; Proteome |
Publicado en: | Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 5635, ISSN 2041-1723 |