Histological deep margins in cutaneous squamous cell carcinoma of the scalp and risk of recurrence
Verdaguer-Faja, Júlia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Guerra-Amor, Álvaro (Hospital Universitari Vall d'Hebron)
Ferrandiz-Pulido, Carla (Hospital Universitari Vall d'Hebron)
Abril-Pérez, Carlos (Hospital Universitari i Politècnic La Fe (València))
Botella Estrada, Rafael (Universitat de València)
Masferrer i Niubò, Emili (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Lopez-Castillo, Daniel (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Deza, Gustavo (Institut Hospital del Mar d'Investigacions Mèdiques)
Leal, Lorena (Institut Hospital del Mar d'Investigacions Mèdiques)
Marti-Marti, Ignasi (Hospital Clínic i Provincial de Barcelona)
Ruiz-Salas, Verónica (Institut d'Investigació Biomèdica Sant Pau)
Yébenes, Mireia (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Marqués Martin, Laura (Hospital de Santa Caterina (Salt, Girona))
Baliu-Piqué, Carola (Hospital Universitari d'Igualada)
Castany, Anna (Hospital Universitari d'Igualada)
Boada, Aram (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Toll, Agustí (Hospital Clínic i Provincial de Barcelona)
Jaka, Ane (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2024
Abstract:	Background: Consensus is lacking on adequate deep histological margins in cutaneous squamous cell carcinoma (cSCC). Deep clearance for tumours located on the scalp is limited by anatomic constraints. Objective: To determine whether clear but close deep histological margins (<1 mm) confer a higher risk of recurrence in cSCCs of the scalp treated by wide local excision, compared to deep histological margins ≥1 mm. Methods: Multicentre retrospective observational cohort study and multivariate competing risk analysis to evaluate risk factors for recurrence. Results: In total, 295 patients with 338 cSCCs were included. Close deep histological margins were not associated with an increased cumulative incidence of recurrence (subhazard ratio [SHR] 1. 96 [95% CI 0. 87-4. 41]). However, an increased risk of recurrence was observed for those tumours that presented concurrent invasion of the galea aponeurotica and close deep margins, as opposed to patients without these factors (SHR 3. 52 [1. 24-10. 01]). Tumours with clear but close peripheral margins (<1 mm) also had higher risk of recurrence (SHR 5. 01 [1. 68-14. 97]). Limitations: Retrospective observational study based on pathology reports. Conclusion: Deep histological margins <1 mm do not confer a greater risk of recurrence as long as the tumour is completely excised and the galea aponeurotica is not involved. Surgical excision of cSCC on the scalp should include the galea to ensure proper assessment of deep margins.
Note:	Altres ajuts: acords transformatius de la UAB
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Journal of the European Academy of Dermatology and Venereology, 2024 , ISSN 1468-3083

DOI: 10.1111/jdv.20250
PMID: 39036869

10 p, 1.5 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles