The Role of Cell Cycle Arrest Biomarkers for Predicting Acute Kidney Injury in Critically Ill COVID-19 Patients : A Multicenter, Observational Study
Weiss, Raphael (University Hospital of Münster (Munster, Alemanya))
Von Groote, Thilo Caspar (University Hospital of Münster (Munster, Alemanya))
Ostermann, Marlies (Guy's & St Thomas' NHS Foundation Trust (Londres, Anglaterra))
Lumlertgul, Nuttha (Chulalongkorn University (Bangkok, Tailàndia))
Weerapolchai, Kittisak (Somdech Phra Pinklao Hospital (Bangkok, Tailàndia))
Monge García, Manuel Ignacio (Hospital Universitario Jerez de la Frontera (Cadis, Andalusia))
Martin Cano, Jose Maria (Hospital Universitario Jerez de la Frontera (Cadis, Andalusia))
Del Corral, Beatriz D. (Hospital Universitario Jerez de la Frontera (Cadis, Andalusia))
Broch-Porcar, María Jesús (Hospital Universitari i Politècnic La Fe (València))
Pérez-Carrasco, Marcos (Hospital Universitari Vall d'Hebron)
De La Vega, Arsenio (Hospital Universitari Vall d'Hebron)
Sousa, Eduardo (Centro Hospitalare e Universitario de Coimbra (Coimbra, Portugal))
Catarino, Ana (Centro Hospitalare e Universitario de Coimbra (Coimbra, Portugal))
Betbesé Roig, Antoni Jordi (Institut d'Investigació Biomèdica Sant Pau)
Baldira Martínez de Irujo, Jaume (Institut d'Investigació Biomèdica Sant Pau)
De Rosa, Silvia (San Bortolo Hospital (Vicenza, Itàlia))
De La Peña, Manuel Garcia Montesinos (Complejo Hospitalario de Navarra)
Tomasa-Irriguible, Teresa Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Brivio, Matteo (Papa Giovanni XXIII Hospital (Bèrgam, Itàlia))
De Molina, Francisco Javier González (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Gerss, Joachim (University of Münster (Munster, Alemanya))
Kellum, John A. (University of Pittsburgh (Pennsilvània, Estats Units d'Amèrica))
Wempe, Carola (University Hospital of Münster (Munster, Alemanya))
Leidereiter, Anna Can (University Hospital of Münster (Munster, Alemanya))
Meersch, Melanie (University Hospital of Münster (Munster, Alemanya))
Zarbock, Alexander (University Hospital of Münster (Munster, Alemanya))
Universitat Autònoma de Barcelona

Fecha:	2023
Resumen:	Patients with COVID-19-associated acute respiratory distress syndrome (ARDS) have a high risk for developing acute kidney injury (AKI) which is associated with an increased risk of death and persistent renal failure. Early prediction of AKI is crucial in order to implement preventive strategies. The purpose of this study was to investigate the predictive performance of tissue inhibitor of metalloproteinases 2 and insulin like growth factor binding protein 7 (TIMP-2) × (IGFBP7) in critically ill patients with COVID-19-associated ARDS. Multicenter, prospective, observational study. Twelve centers across Europe and United Kingdom. Patients with moderate or severe COVID-19-associated ARDS were included and serial measurements of (TIMP-2) × (IGFBP7) were performed. The primary endpoint was the development of moderate or severe AKI according to the Kidney Disease: Improving Global Outcomes definition. Three hundred patients were available for the primary analysis, and 39 met the primary endpoint. At enrollment, urinary (TIMP-2) × (IGFBP7) had high predictive value for the primary endpoint with an area under the receiver operating characteristic curve of 0. 89 (95% CI, 0. 84-0. 93). (TIMP-2) × (IGFBP7) was significantly higher in endpoint-positive patients at enrollment and at 12 hours. Urinary (TIMP-2) × (IGFBP7) predicts the occurrence of AKI in critically ill patients with COVID-19-associated ARDS.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Acute kidney injury ; Biomarkers ; Cell cycle arrest biomarkers ; COVID-19 ; Lung injury ; Tissue inhibitor of metalloproteinases 2 and insulin like growth factor binding protein 7
Publicado en:	Critical Care Medicine, Vol. 51 Núm. 8 (january 2023) , p. 992-1000, ISSN 1530-0293

DOI: 10.1097/CCM.0000000000005853
PMID: 36975308

9 p, 1.1 MB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Recerca Sant Pau
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