Directrices del grupo español de psoriasis (GEP) basadas en la evidencia para el uso de medicamentos biológicos en pacientes con psoriasis en localizaciones de difícil tratamiento (uñas, cuero cabelludo, palmas y plantas) Evidence-Based Guidelines of the Spanish Psoriasis Group on the Use of Biologic Therapy in Patients With Psoriasis in Difficult-to-Treat Sites (Nails, Scalp, Palms, and Soles)
Sánchez-Regaña, Manuel (Hospital Universitari Sagrat Cor (Barcelona, Catalunya))
Aldunce Soto, María José (Hospital Universitari Sagrat Cor (Barcelona, Catalunya))
Belinchón, Isabel (Hospital General Universitario de Alicante (Alacant, País Valencià))
Ribera Pibernat, Miguel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Lafuente-Urrez, Rosario Fátima (Hospital General Universitario Reina Sofía (Múrcia, Múrcia))
Carrascosa, José Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ferrándiz, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Puig Sanz, Lluís (Institut d'Investigació Biomèdica Sant Pau)
Daudén Tello, Esteban (Hospital Universitario de la Princesa (Madrid))
Vidal Sarró, David (Hospital de Sant Joan Despí Moisès Broggi)
Ruíz Villaverde, Ricardo (Complejo Hospitalario de Jaén)
Fonseca, Eduardo (Complejo Hospitalario Universitario de A Coruña)
Rodríguez Cerdeira, Maria del Carmen (Complexo Hospitalario Universitario de Vigo)
Alsina, Mercè (Hospital Clínic i Provincial de Barcelona)
Herrera Acosta, Enrique (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia))
Marrón Moya, S.E. (Hospital de Alcañiz)
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2014
Abstract:	Psoriatic lesions affecting the scalp, nails, palms, and the soles of the feet are described as difficult-to-treat psoriasis and require specific management. Involvement of these sites often has a significant physical and emotional impact on the patient and the lesions are difficult to control with topical treatments owing to inadequate penetration of active ingredients and the poor cosmetic characteristics of the vehicles used. Consequently, when difficult-to-treat sites are involved, psoriasis can be considered severe even though the lesions are not extensive. Scant information is available about the use of biologic therapy in this setting, and published data generally comes from clinical trials of patients who also had moderate to severe extensive lesions or from small case series and isolated case reports. In this article we review the quality of the scientific evidence for the 4 biologic agents currently available in Spain (infliximab, etanercept, adalimumab, and ustekinumab) and report level i evidence for the use of biologics to treat nail psoriasis (level of recommendation A) and a somewhat lower level of evidence in the case of scalp involvement and palmoplantar psoriasis.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Castellà
Document:	Article ; recerca ; Versió publicada
Subject:	Biológicos ; Cuero cabelludo ; Palmas ; Plantas ; Psoriasis ; Uñas
Published in:	Actas dermo-sifiliográficas, Vol. 105 Núm. 10 (enero 2014) , p. 923-934, ISSN 1578-2190

DOI: 10.1016/j.ad.2014.02.015
PMID: 24852726

12 p, 1.1 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles