Albuminuria, Forgotten No More : Underlining the Emerging Role in CardioRenal Crosstalk
Romero-González, Gregorio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rodríguez-Chitiva, Néstor (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Cañameras, Carles (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Paúl-Martínez, Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Urrutia-Jou, Marina (Hospital Universitari Joan XXIII de Tarragona)
Troya, Maribel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Soler-Majoral, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Graterol Torres, Fredzzia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Sánchez-Bayá, Maya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Calabia, Jordi (Institut d'Investigació Biomèdica de Girona)
Bover, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Data:	2024
Resum:	Kidneys have an amazing ability to adapt to adverse situations, both acute and chronic. In the presence of injury, the kidney is able to activate mechanisms such as autoregulation or glomerular hyperfiltration to maintain the glomerular filtration rate (GFR). While these adaptive mechanisms can occur in physiological situations such as pregnancy or high protein intake, they can also occur as an early manifestation of diseases such as diabetes mellitus or as an adaptive response to nephron loss. Although over-activation of these mechanisms can lead to intraglomerular hypertension and albuminuria, other associated mechanisms related to the activation of inflammasome pathways, including endothelial and tubular damage, and the hemodynamic effects of increased activity of the renin-angiotensin-aldosterone system, among others, are recognized pathways for the development of albuminuria. While the role of albuminuria in the progression of chronic kidney disease (CKD) is well known, there is increasing evidence of its negative association with cardiovascular events. For example, the presence of albuminuria is associated with an increased likelihood of developing heart failure (HF), even in patients with normal GFR, and the role of albuminuria in atherosclerosis has recently been described. Albuminuria is associated with adverse outcomes such as mortality and HF hospitalization. On the other hand, it is increasingly known that the systemic effects of congestion are mainly preceded by increased central venous pressure and transmitted retrogradely to organs such as the liver or kidney. With regard to the latter, a new entity called congestive nephropathy is emerging, in which increased renal venous pressure can lead to albuminuria. Fortunately, the presence of albuminuria is modifiable and new treatments are now available to reverse this common risk factor in the cardiorenal interaction.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Ressenya ; recerca ; Versió publicada
Matèria:	Albuminuria ; Cardiorenal disease ; Chronic kidney disease ; Cardiovascular disease ; Heart failure
Publicat a:	Journal of clinical medicine, Vol. 13 Núm. 3 (february 2024) , p. 777, ISSN 2077-0383

DOI: 10.3390/jcm13030777
PMID: 38337471

15 p, 1.1 MB

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