Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke
Zirak, Peyman (Institut de Ciències Fotòniques)
Delgado Mederos, Raquel (Institut d'Investigació Biomèdica Sant Pau)
Dinia, Lavinia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Carrera, David (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau)
Durduran, Turgut (Institut de Ciències Fotòniques)
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2014
Abstract:	The ultimate goal of therapeutic strategies for ischemic stroke is to reestablish the blood flow to the ischemic region of the brain. However, currently, the local cerebral hemodynamics (microvascular) is almost entirely inaccessible for stroke clinicians at the patient bed-side, and the recanalization of the major cerebral arteries (macrovascular) is the only available measure to evaluate the therapy, which does not always reflect the local conditions. Here we report the case of an ischemic stroke patient whose microvascular cerebral blood flow and oxygenation were monitored by a compact hybrid diffuse optical monitor during thrombolytic therapy. This monitor combined diffuse correlation spectroscopy and near-infrared spectroscopy. The reperfusion assessed by hybrid diffuse optics temporally correlated with the recanalization of the middle cerebral artery (assessed by transcranial-Doppler) and was in agreement with the patient outcome. This study suggests that upon further investigation, diffuse optics might have a potential for bed-side acute stroke monitoring and therapy guidance by providing hemodynamics information at the microvascular level.
Grants:	Ministerio de Ciencia e Innovación PS09/00557
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Journal of Biomedical Optics, Vol. 19 Núm. 1 (january 2014) , p. 18002, ISSN 1560-2281

DOI: 10.1117/1.JBO.19.1.018002
PMID: 24413455

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles