Therapeutic development paths for cognitive impairment in Parkinson's disease : Report of a regulatory roundtable
Eberling, Jamie (Michael J. Fox Foundation for Parkinson's Research)
Vincent, Lona (Michael J. Fox Foundation for Parkinson's Research)
Goldman, Jennifer G. (Rush University Medical Center (Chicago, Estats Units))
Weintraub, Daniel (University of Pennsylvania (Philadelphia, Estats Units))
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau)
Marras, Connie (University of Toronto (Canadà))
Stebbins, Glenn (Rush University Medical Center (Chicago, Estats Units))
Kieburtz, Karl (University of Rochester (Nova York, Estats Units))
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2014
Abstract:	Cognitive impairment is a common occurrence in Parkinson's disease (PD), although the severity and specific presentation varies across patients. Initial deficits, including mild cognitive impairment (PD-MCI), may remain stable or in many cases, may progress over variable lengths of time to Parkinson's disease dementia (PDD). As there are currently no marketed treatments for milder forms of cognitive impairment, an opportunity exists to define the path for therapeutic development in this area. In the absence of a well-defined path for the approval of therapies that target PD-MCI, pharmaceutical companies are unlikely to pursue this indication. In order to move forward and improve the quality of life for PD patients, it is imperative for the field to have consensus on the definition of PD-MCI, the best instruments to measure cognitive decline, and a strategy for future clinical trials.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Clinical trial ; Cognition ; FDA ; Parkinson's
Published in:	Journal of Parkinson's Disease, Vol. 4 Núm. 4 (2014) , p. 585-589, ISSN 1877-718X

DOI: 10.3233/JPD-140385
PMID: 24989876

8 p, 70.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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