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| Pàgina inicial > Articles > Articles publicats > Mussel-Inspired Multifunctional Polyethylene Glycol Nanoparticle Interfaces |
(Institut Català de Nanociència i Nanotecnologia) (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) (Universitat Autònoma de Barcelona. Departament de Química) (Universitat Autònoma de Barcelona. Departament de Química) (Institut Català de Nanociència i Nanotecnologia)
| Data: | 2024 |
| Resum: | Nanoparticles (NPs) are receiving increasing interest in biomedical applications. However, due to their large surface area, in physiological environments, they tend to interact with plasma proteins, inducing their agglomeration and ultimately resulting in a substantial efficiency decrease in diagnostic and therapeutic applications. To overcome such problems, NPs are typically coated with a layer of hydrophilic and biocompatible polymers, such as PEG chains. However, few examples exist in which this property could be systematically fine-tuned and combined with added properties, such as emission. Herein, we report a novel mussel-inspired catechol-based strategy to obtain biocompatible and multifunctional coatings, using a previously developed polymerization methodology based on the formation of disulfide bridges under mild oxidative conditions. Two families of NPs were selected as the proof of concept: mesoporous silica NPs (MSNPs), due to their stability and known applications, and magnetite NPs (FeO NPs), due to their small size (<10 nm) and magnetic properties. The PEG coating confers biocompatibility on the NPs and can be further functionalized with bioactive molecules, such as glucose units, through the end carboxylic acid moieties. Once we demonstrated the feasibility of our approach to obtaining PEG-based coatings on different families of NPs, we also obtained multifunctional coatings by incorporating fluorescein functionalities. The resulting coatings not only confer biocompatibility and excellent cell internalization, but also allow for the imaging and tracking of NPs within cells. |
| Ajuts: | Agencia Estatal de Investigación PID2019-106403RB-I00 Agencia Estatal de Investigación PID2021-127983OB-C21 Agencia Estatal de Investigación PID2021-127983OB-C22 Agencia Estatal de Investigación PID2022-139826OB-I00 Agencia Estatal de Investigación SEV-2017-0706 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Catechol ; Functional coatings ; Bioinspired ; Functional nanoparticles ; Biocompatible ; Magnetite NPs ; MSNPs |
| Publicat a: | Biomimetics, Vol. 9, Issue 9 (September 2024) , art. 531, ISSN 2313-7673 |
