PATH classification : a proposal for patients with HNSCC treated with salvage surgery
Llansana, Albert (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Virós Porcuna, David (Vall d'Hebron Institut de Recerca (VHIR))
Vásquez, Rosselin (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Parellada, Arnau (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Valero Mayor, Cristina (Institut de Recerca Sant Pau)
Holgado, Anna (Institut de Recerca Sant Pau)
León i Vintró, Xavier (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Purpose: The aim of this study is to propose a classification for patients with recurrent head and neck squamous cell carcinoma (HNSCC) treated with salvage surgery based on the location of the primary tumor and data commonly found in the pathological report of the resection. Methods: Retrospective study of 665 patients with HNSCC treated with a salvage surgery after a local and/or regional recurrence of the tumor. Results: We propose a new postoperative classification for patients with recurrent HNSCC treated with salvage surgery. PATH classification stratifies patients into 4 stages based on the glottic or non-glottic location of the primary tumor, the local and regional pathologic extension of the tumor, the status of the surgical margins, and the presence of lymph node metastases with extracapsular spread. The PATH classification was more homogeneous in the prognosis of patients included in each of its stages, and it had a better prognostic discrimination capacity between stages than the rpTNM classification. According to the PATH classification, the 5-year disease-specific survival was: PATH I (n = 306) 82. 8%; PATH II (n = 119) 47. 1%; PATH III (n = 202) 24. 4%; PATH IV (n = 38) 3. 7%. For the rpTNM classification, the 5-year disease-specific survival was: stage I (n = 119) 85. 1%; stage II (n = 134) 68. 4%; stage III (n = 111) 59. 5%; stage IV (n = 301) 33. 3%. Conclusion: The PATH classification for HNSCC patients with local and/or regional recurrence treated with salvage surgery had a better prognostic capacity than the rpTNM classification. Level of evidence: Level IV.
Ajuts:	Instituto de Salud Carlos III PI19/01661
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Head and neck cancer ; Recurrent disease ; Salvage surgery ; Rptnm ; Postoperative prognostic classification
Publicat a:	European archives of oto-rhino-laryngology, 2024 , ISSN 1434-4726

DOI: 10.1007/s00405-024-08961-x
PMID: 39312000

9 p, 1.0 MB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
Articles > Articles de recerca
Articles > Articles publicats