Lipidome Profiling in Childhood Obesity Compared to Adults : A Pilot Study
Soria-Gondek, Andrea (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Fernández-García, Pablo (University Rey Juan Carlos (URJC))
González, Lorena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Reyes-Farias, Marjorie (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Murillo, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Valls, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Real, Nativitat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Pellitero, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Tarascó, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Jenkins, Benjamin (University of Cambridge)
Galán, María (University Rey Juan Carlos (URJC))
Villarroya, Francesc (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición)
Koulman, Albert (University of Cambridge)
Corrales, Patricia (University Rey Juan Carlos (URJC))
Vidal-Puig, Antonio (University of Cambridge)
Cereijo, Rubén (Institut d'Investigació Biomèdica Sant Pau)
Sánchez-Infantes, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	The objective is to assess the circulating lipidome of children with obesity before and after lifestyle intervention and to compare the data to the circulating lipidome of adults with obesity before and after bariatric surgery. Ten pediatric (PE) and thirty adult (AD) patients with obesity were prospectively recruited at a referral single center. The PE cohort received lifestyle recommendations. The AD cohort underwent bariatric surgery. Clinical parameters and lipidome were analyzed in serum before and after six months of metabolic intervention. The abundance of phosphatidylinositols in the PE cohort and phosphatidylcholines in the AD significantly increased, while O-phosphatidylserines in the PE cohort and diacyl/triacylglycerols in the AD decreased. Fifteen lipid species were coincident in both groups after lifestyle intervention and bariatric surgery. Five species of phosphatidylinositols, sphingomyelins, and cholesteryl esters were upregulated. Eight species of diacylglycerols, glycerophosphoglycerols, glycerophosphoethanolamines, and phosphatidylcholines were downregulated. Most matching species were regulated in the same direction except for two phosphatidylinositols: PI(O-36:2) and PI(O-34:0). A specific set of lipid species regulated after bariatric surgery in adult individuals was also modulated in children undergoing lifestyle intervention, suggesting they may constitute a core circulating lipid profile signature indicative of early development of obesity and improvement after clinical interventions regardless of individual age.
Grants:	Instituto de Salud Carlos III PI20/00807 Instituto de Salud Carlos III PI17/01455
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Bariatric surgery ; Childhood obesity ; Lipidomics
Published in:	Nutrients, Vol. 15 Núm. 15 (august 2023) , p. 3341, ISSN 2072-6643

DOI: 10.3390/nu15153341
PMID: 37571279

17 p, 2.8 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles