Prospective Investigation of Nanoplastic Accumulation in Healthy Subjects, Autoimmune Diseases, Hematological Malignancies, Lung Cancer, and Murine Models
Salvia, Roser (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Cañaveras, Manel (Institut Germans Trias i Pujol)
G. Rico, Laura (Institut Germans Trias i Pujol)
Drozdowskyj, Ana (Hospital Universitari Dexeus)
Ward, Michael D. (Thermo Fisher Scientific)
Jurado, Rebeca (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Gómez Muñoz, Laia (Institut Germans Trias i Pujol)
Vives-Pi, Marta (Institut Germans Trias i Pujol)
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Petriz, Jordi (Institut Germans Trias i Pujol)

Date:	2025
Abstract:	Nanoplastics (NPs) and microplastics (MPs) are an emerging threat to global health. They negatively impact ecosystems and many physiological processes, causing alterations in xenobiotic metabolism, nutrient uptake, energy metabolism, or cytotoxicity. In humans, we are beginning to analyze these plastics for the mechanisms by which they enter the organism, accumulate, and diffuse as well as for their pathogenic potential. NP accumulation has been demonstrated in human tissues, such as blood or placenta, while in others it remains largely unstudied. In this work, we detected NP accumulation in bronchoalveolar lavage fluids (BALFs), cerebrospinal fluids (CSFs), lymph nodes (LNs), urine, pleural fluids (PFs), ascitic fluids (AFs), and peripheral blood (PB) by combining fluorescence and nanocytometry techniques. NP analysis was compared with two strains of mice, and the results support that inhalation is the main route of NP accumulation.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00002
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Nanoplastics ; Detection ; Accumulation ; Human ; Mice ; Flow cytometry ; Nanocytometry
Published in:	Microplastics, Vol. 4 Núm. 1 (2025) , ISSN 2673-8929

DOI: 10.3390/microplastics4010001

15 p, 1.9 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles