Age of Alzheimer's disease diagnosis in people with Down syndrome and associated factors : Results from the Horizon 21 European Down syndrome consortium
Larsen, Frode Kibsgaard (University of Oslo)
Baksh, Asaad (London Down Syndrome Consortium (LonDownS))
McGlinchey, Eimear (Trinity College Dublin & University of California)
Langballe, Ellen Melbye (Oslo University Hospital (Oslo, Noruega))
Benejam, Bessy (Fundació Catalana Síndrome de Down)
Beresford-Webb, Jessica (Fulbourn Hospital)
McCarron, Mary (Trinity College Dublin)
Coppus, Antonia (Radboud University Medical Center)
Falquero, Segolene (Institute Jerome Lejeune)
Fortea, Juan (Institut de Recerca Sant Pau)
Levin, Johannes (Munich Cluster for Systems Neurology (SyNergy))
Loosli, Sandra V. (University Hospital Zurich (Suïssa))
Mark, Ruth (Tilburg University)
Rebillat, Anne-Sophie (Institute Jerome Lejeune)
Zaman, Shahid (Fulbourn Hospital)
Strydom, Andre (South London and the Maudsley NHS Foundation Trust)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	INTRODUCTION: People with Down syndrome (DS) have high risk of developing Alzheimer's disease (AD). This study examined mean ages of AD diagnosis and associations with co-occurring conditions among adults with DS from five European countries. METHODS: Data from 1335 people with DS from the Horizon 21 European DS Consortium were used for the analysis. RESULTS: Mean ages of AD diagnosis ranged between 51. 4 (SD 7. 0) years (United Kingdom) and 55. 6 (SD 6. 8) years (France). Sleep-related and mental health problems were associated with earlier age of AD diagnosis. The higher number of co-occurring conditions the more likely the person with DS is diagnosed with AD at an earlier age. DISCUSSION: Mean age of AD diagnosis in DS was relatively consistent across countries. However, co-occurring conditions varied and impacted on age of diagnosis, suggesting that improvements can be made in diagnosing and managing these conditions to delay onset of AD in DS. Highlights: Mean age of AD diagnosis was relatively consistent between countries Sleep problems and mental health problems were associated with earlier age of AD diagnosis APOE ε4 carriers were diagnosed with AD at an earlier age compared to non-carriers Number of co-occurring conditions was associated with earlier age of AD diagnosis No differences between level of intellectual disability and mean age of AD diagnosis.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Alzheimer's disease ; Down syndrome ; Age of diagnosis ; Co-occurring conditions
Publicat a:	Alzheimer's & dementia, Vol. 20 Núm. 5 (may 2024) , p. 3270-3280, ISSN 1552-5279

DOI: 10.1002/alz.13779
PMID: 38506627

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