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| Home > Articles > Published articles > Increased grey matter volumes in the temporal lobe and its relationship with cognitive functioning in euthymic patients with bipolar disorder |
(Institut de Recerca Sant Pau) (Institut de Recerca Sant Pau) (Institut Català d'Oncologia) (Institut de Salut Carlos III) (Hospital Clínic i Provincial de Barcelona) (Hospital Clínic i Provincial de Barcelona) (Hospital Clínic i Provincial de Barcelona) (Hospital Clínic i Provincial de Barcelona) (Institut de Recerca Sant Pau) (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) (Hospital Clínic i Provincial de Barcelona) (Institut de Recerca Sant Pau) (Institut de Salut Carlos III)| Date: | 2024 |
| Abstract: | Bipolar disorder (BD) is characterized by episodic mood dysregulation, although a significant portion of patients suffer persistent cognitive impairment during euthymia. Previous magnetic resonance imaging (MRI) research suggests BD patients may have accelerated brain aging, observed as lower grey matter volumes. How these neurostructural alterations are related to the cognitive profile of BD is unclear. We aim to explore this relationship in euthymic BD patients with multimodal structural neuroimaging. A sample of 27 euthymic BD patients and 24 healthy controls (HC) underwent structural grey matter MRI and diffusion-weighted imaging (DWI). BD patient's cognition was also assessed. FreeSurfer algorithms were used to obtain estimations of regional grey matter volumes. White matter pathways were reconstructed using TRACULA, and four diffusion metrics were extracted. ANCOVA models were performed to compare BD patients and HC values of regional grey matter volume and diffusion metrics. Global brain measures were also compared. Bivariate Pearson correlations were explored between significant brain results and five cognitive domains. Euthymic BD patients showed higher ventricular volume (F(1, 46) = 6. 04; p = 0. 018) and regional grey matter volumes in the left fusiform (F(1, 46) = 15. 03; pFDR = 0. 015) and bilateral parahippocampal gyri compared to HC (L: F(1, 46) = 12. 79, pFDR = 0. 025/ R: F(1, 46) = 15. 25, pFDR = 0. 015). Higher grey matter volumes were correlated with greater executive function (r = 0. 53, p = 0. 008). We evaluated a modest sample size with concurrent pharmacological treatment. Higher medial temporal volumes in euthymic BD patients may be a potential signature of brain resilience and cognitive adaptation to a putative illness neuroprogression. This knowledge should be integrated into further efforts to implement imaging into BD clinical management. |
| Grants: | Ministerio de Economía y Competitividad PI15/00330 Instituto de Salud Carlos III PI17/01066 Instituto de Salud Carlos III PI18/00805 Instituto de Salud Carlos III PI20/00344 Instituto de Salud Carlos III PI21/00787 Instituto de Salud Carlos III PI21/01756 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1365 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1292 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Bipolar disorder ; Cognition ; Multimodal imaging ; Structural neuroimaging |
| Published in: | Progress in neuro-psychopharmacology & biological psychiatry, Vol. 132 (august 2024) , p. 110962, ISSN 1878-4216 |
