The Polypill : A New Alternative in the Prevention and Treatment of Cardiovascular Disease
Páez Espinosa, Enma V. (Pontifical Catholic University of Ecuador)
Mato, Eugènia (Institut de Recerca Sant Pau)
Sosa Guzmán, Delia M. (Pontifical Catholic University of Ecuador)
Khasawneh, Fadi T. (Texas A&M University)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Cardiovascular disease (CVD) is the primary cause of death and disability worldwide. Although age-standardized CVD mortality rates decreased globally by 14. 5% between 2006 and 2016, the burden of CVD remains disproportionately higher in low- and middle-income countries compared to high-income countries. Even though proven, effective approaches based on multiple-drug intake aimed at the prevention and treatment of CVD are currently available, poor adherence, early discontinuation of treatment, and suboptimal daily execution of the prescribed therapeutic regimes give rise to shortfalls in drug exposure, leading to high variability in the responses to the prescribed medications. Wald and Law, in their landmark paper published in BMJ 2003, hypothesized that the use of a fixed-dose combination of statins, β-blockers, angiotensin receptor blockers, angiotensin-converting enzyme inhibitors, and aspirin (classic Polypill composition) may increase adherence and decrease CVD by up to 80% when prescribed as primary prevention or in substitution of traditional protocols. Since then, many clinical trials have tested this hypothesis, with comparable results. This review aims to describe the available clinical trials performed to assess the impact of fixed-dose combinations on adherence, cost-effectiveness, and the risk factors critical to the onset of CVD.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Matèria:	LDL cholesterol ; Adherence ; Cardiovascular disease ; Cost ; Efficiency ; Hypertension ; Polypill ; Randomized clinical trials
Publicat a:	Journal of clinical medicine, Vol. 13 Núm. 11 (june 2024) , p. 3179, ISSN 2077-0383

DOI: 10.3390/jcm13113179
PMID: 38892892

33 p, 639.5 KB

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