The Lipidomic Profile Is Associated with the Dietary Pattern in Subjects with and without Diabetes Mellitus from a Mediterranean Area
Rojo López, Marina Idalia (Institut de Recerca Sant Pau)
Barranco-Altirriba, Maria (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Rossell, Joana (Institut de Recerca Sant Pau)
Antentas Peraile, María (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Castelblanco, Esmeralda (Washington University School of Medicine)
Yanes, Oscar (Universitat Rovira i Virgili)
Weber, Ralf J.M. (University of Birmingham)
Lloyd, Gavin R. (University of Birmingham)
Winder, Catherine (University of Liverpool)
Dunn, Warwick B. (University of Liverpool)
Julve i Gil, Josep (Institut de Recerca Sant Pau)
Granado-Casas, Minerva (Universitat de Lleida)
Mauricio Puente, Dídac (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Lipid functions can be influenced by genetics, age, disease states, and lifestyle factors, particularly dietary patterns, which are crucial in diabetes management. Lipidomics is an expanding field involving the comprehensive exploration of lipids from biological samples. In this cross-sectional study, 396 participants from a Mediterranean region, including individuals with type 1 diabetes (T1D), type 2 diabetes (T2D), and non-diabetic individuals, underwent lipidomic profiling and dietary assessment. Participants completed validated food frequency questionnaires, and lipid analysis was conducted using ultra-high-performance liquid chromatography coupled with mass spectrometry (UHPLC/MS). Multiple linear regression models were used to determine the association between lipid features and dietary patterns. Across all subjects, acylcarnitines (AcCa) and triglycerides (TG) displayed negative associations with the alternate Healthy Eating Index (aHEI), indicating a link between lipidomic profiles and dietary habits. Various lipid species (LS) showed positive and negative associations with dietary carbohydrates, fats, and proteins. Notably, in the interaction analysis between diabetes and the aHEI, we found some lysophosphatidylcholines (LPC) that showed a similar direction with respect to aHEI in non-diabetic individuals and T2D subjects, while an opposite direction was observed in T1D subjects. The study highlights the significant association between lipidomic profiles and dietary habits in people with and without diabetes, particularly emphasizing the role of healthy dietary choices, as reflected by the aHEI, in modulating lipid concentrations. These findings underscore the importance of dietary interventions to improve metabolic health outcomes, especially in the context of diabetes management.
Ajuts:	Ministerio de Economía y Competitividad CB15/00071
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Diabetes ; Dietary pattern ; Lipid species ; Lipidomic
Publicat a:	Nutrients, Vol. 16 Núm. 12 (august 2024) , ISSN 2072-6643

DOI: 10.3390/nu16121805
PMID: 38931159

15 p, 1.5 MB

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