The Influence of Metabolic Risk Factors on the Inflammatory Response Triggered by Myocardial Infarction : Bridging Pathophysiology to Treatment
Ramos-Regalado, Lisaidy (Universitat de Barcelona)
Badimon, Lina (Institut de Recerca Sant Pau)
Vilahur, Gemma (Institut de Recerca Sant Pau)
Alcover, Sebastià (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Myocardial infarction (MI) sets off a complex inflammatory cascade that is crucial for effective cardiac healing and scar formation. Yet, if this response becomes excessive or uncontrolled, it can lead to cardiovascular complications. This review aims to provide a comprehensive overview of the tightly regulated local inflammatory response triggered in the early post-MI phase involving cardiomyocytes, (myo)fibroblasts, endothelial cells, and infiltrating immune cells. Next, we explore how the bone marrow and extramedullary hematopoiesis (such as in the spleen) contribute to sustaining immune cell supply at a cardiac level. Lastly, we discuss recent findings on how metabolic cardiovascular risk factors, including hypercholesterolemia, hypertriglyceridemia, diabetes, and hypertension, disrupt this immunological response and explore the potential modulatory effects of lifestyle habits and pharmacological interventions. Understanding how different metabolic risk factors influence the inflammatory response triggered by MI and unraveling the underlying molecular and cellular mechanisms may pave the way for developing personalized therapeutic approaches based on the patient's metabolic profile. Similarly, delving deeper into the impact of lifestyle modifications on the inflammatory response post-MI is crucial. These insights may enable the adoption of more effective strategies to manage post-MI inflammation and improve cardiovascular health outcomes in a holistic manner.
Grants:	Agencia Estatal de Investigación PID2021-128891OB-I00 Agencia Estatal de Investigación PID2019-107160RB-I00 Ministerio de Economía y Competitividad CB16/11/00411 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1480
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Bone marrow ; Inflammatory response ; Innate immune response ; Lifestyle modifications ; Metabolic risk factors ; Myocardial infarction ; Pharmacological interventions ; Spleen
Published in:	Cells, Vol. 13 Núm. 13 (july 2024) , p. 1125, ISSN 2073-4409

DOI: 10.3390/cells13131125
PMID: 38994977

18 p, 2.7 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles