Binge drinking at time of bariatric surgery is associated with liver disease, suicides, and increases long-term mortality
Alvarado-Tapias, Edilmar (Institut de Recerca Sant Pau)
Martí-Aguado, D. (Instituto de Salud Carlos III)
Gómez-Medina, C. (INCLIVA Institut d'Investigació Sanitària)
Ferrero-Gregori, Andreu (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Szafranska, Justyna (Institut de Recerca Sant Pau)
Brujats Rubirola, Anna (Institut de Recerca Sant Pau)
Osuna Gómez, Rubén (Institut de Recerca Sant Pau)
Alfaro-Cervelló, C. (Universitat de València)
Pose, Elisa (Hospital Clínic i Provincial de Barcelona)
Ventura-Cots, Meritxell (Hospital Universitari Vall d'Hebron)
Fernández-Carrillo, C. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Cabezas González, Joaquín (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
López-Pelayo, Hugo (Hospital Clínic i Provincial de Barcelona)
Arab, Juan Pablo (Pontificia Universidad Católica de Chile)
Argemi, J. (Universidad de Navarra)
Bataller, Ramon (Hospital Clínic i Provincial de Barcelona)
Guinart Cuadra, Albert (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Clemente, Ana (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Contreras, Cynthia (Good Samaritan Hospital. Trihealth)
Universitat Autònoma de Barcelona. Departament de Medicina

Data:	2024
Resum:	Background and Aims: Alcohol use disorder has been reported in patients undergoing bariatric procedures, but the pattern of alcohol consumption has not been evaluated. We investigated the prevalence, risk factors, and impact of binge drinking (BD) at the time of surgery and during follow-up. Methods: A prospective, longitudinal study of subjects undergoing bariatric surgery was included in the LABS-2 registry between 2006 and 2009. Participants with AUDIT questionnaire at the time of surgery and a minimum of 12 months follow-up were included. BD was defined as consuming ≥5 drinks on at least 1 occasion in the previous month. Liver biopsies were obtained during bariatric procedures in not all cases. Survival analysis was performed with the adjusted Cox regression model and competing risk. Results: A total of 2257 subjects were included, with a median follow-up of 79 months. The prevalence of BD at time of surgery was 12%, and it raised up to 23% during follow-up. Patients with BD predominantly had a binge eating disorder (OR=1. 35 [95% CI: 1. 04-1. 76]), regularly consumed fast food [OR=1. 4 (95% CI: 1. 07-1. 85)] and used other drugs (OR=2. 65 [95% CI: 1. 74-4. 04]). Within liver biopsies evaluation, BD showed higher hepatic iron deposits (OR=3. 00 [95% CI: 1. 25-7. 21]). BD at the time of surgery was associated with a higher risk of BD during follow-up (OR=10. 49 [95% CI: 7. 86-14. 00]) and long-term mortality (HR: 3. 21 [95% CI: 1. 67-6. 18]). Specific causes of death in these patients with BD were liver disease (p=0. 020), suicide (p=0. 015), neoplasms (p=0. 034), and respiratory (p=0. 025). Conclusions: The prevalence of BD in patients undergoing bariatric surgery is high and increases the risk of postoperative liver disease, suicides, and long-term mortality.
Ajuts:	Instituto de Salud Carlos III PI21/01995 Instituto de Salud Carlos III PI22/01770
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Hepatology Communications, Vol. 8, Num. 8 (July 2024) , art. e0490, ISSN 2471-254X

DOI: 10.1097/HC9.0000000000000490
PMID: 39037383

15 p, 1.3 MB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
Articles > Articles de recerca
Articles > Articles publicats