Clinical and research application of fluid biomarkers in autosomal dominant Alzheimer's disease and Down syndrome
Carmona Iragui, Maria (Institut de Recerca Sant Pau)
O'Connor, A. (Tallaght University Hospital)
Llibre-Guerra, J. (Washington University School of Medicine in St.Louis)
Lao, P. (G.H. Columbia University Irving Medical Center)
Ashton, Nicholas J. (Stavanger University Hospital)
Fortea, Juan (Institut de Recerca Sant Pau)
Sanchez-Valle, Raquel (Hospital Clínic i Provincial de Barcelona)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Autosomal dominant Alzheimer's disease (ADAD) and Down syndrome (DS) constitute genetic forms of Alzheimer's disease (AD). The study of these forms has been crucial in understanding the biomarker changes and disease progression, notably in advancing our knowledge of the natural history of AD. However, some specific characteristics of biomarkers in genetically determined forms and, most importantly, the near full penetrance and predictability of disease onset lead to a very different context of use for biomarkers in these populations. This article delves into the similarities and differences in biomarker profiles between genetically determined AD and sporadic cases, discussing the implications for research and clinical practice. It also emphasizes the need to account for factors that may affect biomarker reliability differently in genetically determined AD. Enhancing our understanding of the disease will pave the way for more personalized therapeutic approaches for affected individuals.
Grants:	Instituto de Salud Carlos III PI18/00335 Instituto de Salud Carlos III PI20/01473 Instituto de Salud Carlos III PI23/01786
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Alzheimer ; Autosomal dominant Alzheimer's disease ; Biofluids ; Biomarkers ; Down syndrome
Published in:	EBioMedicine, Vol. 108 (october 2024) , p. 105327, ISSN 2352-3964

DOI: 10.1016/j.ebiom.2024.105327
PMID: 39366843

12 p, 1.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles