Delabelling beta-lactam allergy
Molina-Molina, Gustavo-Jorge (Hospital Universitari de Bellvitge)
Garnica Velandia, Diana Rocío (Institut de Recerca Biomèdica de Lleida)
Andrés-López, Blanca (Hospital Universitari de Bellvitge)
Perales, Carolina (Hospital de Tortosa Verge de la Cinta)
Marin-Asensio, Laura (Hospital de Tortosa Verge de la Cinta)
Jurgens, Yanina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Esteso, Olga (Hospital Universitari Joan XXIII de Tarragona)
Escobar Bolaños, Carolina (Hospital Universitari de Girona Doctor Josep Trueta)
Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron)
Vendrell, Lourdes (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Gómez-Ganda, Laura (Hospital Universitari Vall d'Hebron)
Rodríguez, Dolores (Hospital Universitari de Bellvitge)
Montané Esteva, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Cardona, Victoria (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Agustí Escasany, M. Antònia (Hospital Universitari Vall d'Hebron)

Data:	2024
Resum:	Background: Hypersensitivity to beta-lactam (BL) antibiotics is one of the most frequent reported drug allergies. In our population, it is common to find labels of BL allergy in electronic medical records (EMRs) that have not been assessed. The objective of our study was to detect patients with beta-lactam allergy labels in their EMRs and to assess how many of them are false after a correct diagnostic evaluation. Methods: A multicentre prospective study was performed with patients labelled as allergic to BLs in their EMRs in the previous 5 years. Demographical and clinical data, as well as variables regarding the BL allergy label and the characteristics of the index reaction from clinical history and EMRs, were recorded. Then, diagnostic assessments including clinical history, skin tests (STs), and drug provocation tests (DPTs) were conducted in order to confirm or exclude the diagnosis of BL allergy. Results: A total of 249 patients completed the study, of which 160 (64. 3%) were women with a median age of 57 years (interquartile range [IQR], 45-68). The most frequent BL allergy labels detected were for penicillin (124), amoxicillin/clavulanic acid (61), and amoxicillin (54). Of the 204 patients who underwent STs, 20. 1% were positive. DPTs were performed in 224 patients, showing good tolerance in 87. 1% of cases. After the allergy diagnosis work-up, 186 patients (74. 7%) were diagnosed as non-allergic to BL antibiotics. Conclusion: In our study population, the number of patients labelled as allergic to BLs in their EMRs was similar to that in previously published studies, with proportions near to 75%-80% being falsely labelled as allergic to BLs.
Ajuts:	Instituto de Salud Carlos III PI19/01656
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Beta-lactam ; Delabelling ; Drug provocation test ; Electronic medical records ; Skin test ; Penicillin
Publicat a:	Frontiers in Pharmacology, Vol. 15 (June 2024) , ISSN 1663-9812

DOI: 10.3389/fphar.2024.1423719
PMID: 38994200

11 p, 1.8 MB

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