Walking one hour per day and the derived neutrophil-to-lymphocyte ratio are associated with outcome in palliative second-line immunotherapy for patients with recurrent and/or metastatic squamous cell carcinoma of head and neck
Caballero-Borrego, Miguel (Hospital Clínic i Provincial de Barcelona)
Piedra, Aida (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Gallego Rubio, Oscar (Institut de Recerca Sant Pau)
López Pousa, Antonio (Institut de Recerca Sant Pau)
Castillo, Paola (Hospital Clínic i Provincial de Barcelona)
Navarrete, P. (Universitat de Barcelona)
Prat, Alba (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Grau, Juan Jose (Hospital Clínic i Provincial de Barcelona)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Objectives: To determine whether routinary walking activity and the derived neutrophil-to-lymphocyte ratio are associated with outcomes in patients with recurrent and/or metastatic squamous cell carcinoma of head and neck. Methods: This multicenter retrospective cohort study included 64 patients diagnosed with recurrent and/or metastatic squamous cell carcinoma of head and neck and treated with immunotherapy (Programmed Death-1 and Programmed Death-ligand-1 proteins inhibitors) at two tertiary centers. We compared a group that performed uninterrupted physical activity for 1 h per day and controls who performed no activity. The derived neutrophil-to-lymphocyte ratio was calculated as follows: [neutrophils / (leukocytes - neutrophils)]. Progression-free survival and overall survival were evaluated. Results: We included 28 (44%) and 36 (56%) patients in the activity and non-activity groups, respectively. Patient characteristics, treatment details, and tumor Programmed Death-ligand-1 expression were not associated with either progression-free survival or overall survival. Physical activity was an independent beneficial factor for progression-free survival (p < 0. 001) and overall survival (p < 0. 001). By contrast, a derived neutrophil-to-lymphocyte ratio <3. 5 was an independent beneficial factor for overall survival (p = 0. 013), but not for progression-free survival (p = 0. 328). Conclusions: Walking one hour per day and having a high proportion of lymphocytes to neutrophiles (expressed as a low derived neutrophil-to-lymphocyte ratio) independently predict a better prognosis in patients with recurrent and/or metastatic squamous cell carcinoma of head and neck treated with immunotherapy. Level of evidence: III.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Derived neutrophil-to-lymphocyte ratio ; Head and neck cancer ; Immunotherapy ; Physical activity ; Prognosis
Publicat a:	Brazilian Journal of Otorhinolaryngology, Vol. 90 Núm. 6 (january 2024) , p. 101493, ISSN 1808-8686

DOI: 10.1016/j.bjorl.2024.101493
PMID: 39205362

8 p, 949.6 KB

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