Intradialytic Parenteral Nutrition in Patients on Hemodialysis : A Multicenter Retrospective Study
Arias-Guillén, Marta (Hospital Clínic i Provincial de Barcelona)
González, J.C. (Hospital de Mollet)
Betancourt Castellanos, Loreley (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Coll Piera, Elisabeth (Institut de Recerca Sant Pau)
Collado, S (Hospital del Mar (Barcelona, Catalunya))
Romano, Bárbara (Hospital Clínic i Provincial de Barcelona)
Lupiañez-Barbero, A. (Diaverum Serveis Renals)
Garro, J. (Hospital Universitari Joan XXIII de Tarragona)
Duarte Gallego, Verónica (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Soler Majoral, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Calabia, Jordi (Hospital Universitari de Girona Doctor Josep Trueta)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Background and Objective: To evaluate the effectiveness and safety of intradialytic parenteral nutrition (IDPN) on different nutritional outcomes. Methods: This was a retrospective analysis for a "routinely collected data bank" in a multicenter cohort, conducted on consecutive malnourished or at-risk of malnutrition patients with chronic kidney disease on hemodialysis who underwent IDPN with a three-in-one parenteral nutrition formula for a period ≥ 2 weeks. The primary endpoint was the mean change in the malnutrition inflammation score (MIS) score between baseline and the last follow-up visit on IDPN. Results: Fifty-six patients were included. The mean age was 72. 4 ± 12. 0 years, and 24 (42. 9%) were women. In the overall study sample, MIS significantly decreased from 16. 4 (95%CI: 15. 3-17. 65) at baseline to 14. 3 (95%CI: 12. 8-15. 8) at the last follow-up visit on IDPN (p = 0. 0019). Fifteen (26. 8%) patients achieved a MIS reduction ≥ 5 points after IDPN. As compared to baseline, IDPN significantly reduced the proportion of patients with protein-energy wasting (PEW) (89. 3% versus 66. 1%, respectively, p = 0. 0023). Regarding analytical parameters, serum albumin (p = 0. 0003) and total proteins (p = 0. 0024) significantly increased after IDPN administration. Throughout the study's follow-up period, 45 (80. 4%) patients reported experiencing some type of adverse event. Conclusions: IDPN was associated with a significant improvement in the nutritional profile. Notably, our research found that the administration of IDPN over a duration > 3 months significantly improved the nutritional status of patients evaluated by the MIS test.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Chronic kidney disease ; Hemodialysis ; Intradialytic parenteral nutrition ; Malnutrition inflammation score ; Protein-energy wasting
Published in:	Nutrients, Vol. 16 Núm. 23 (december 2024) , p. 4018, ISSN 2072-6643

DOI: 10.3390/nu16234018
PMID: 39683411

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The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles