Zoonotic tuberculosis in Catalonia, Spain : Phylogenetic insights into Mycobacterium bovis and M. caprae transmission at the human-livestock interface
Pérez de Val, Bernat (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal)
Vidal Barba, Enric (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal)
Stuber, Tod (U.S. Department of Agriculture. National Veterinary Services Laboratories)
Sáez, Jose Luís (Espanya. Ministerio de Agricultura, Pesca y Alimentación. Dirección General de Sanidad de la Producción Agraria)
Tórtola Fernández, María Teresa (Instituto de Salud Carlos III)

Date:	2025
Abstract:	This genomic epidemiology study analyzed Mycobacterium bovis and M. caprae isolates from animals and humans in Catalonia, Spain, between 2005 and 2023. Of 42 human tuberculosis (TB) cases, five were phylogenetically linked to livestock outbreaks, suggesting zoonotic transmission. The findings specifically indicate goats as a primary source of M. caprae transmission to humans. The study also revealed unexpected genetic diversity of mycobacteria within the same outbreak or even within the same patient, highlighting the complexity of tuberculosis transmission dynamics. The results underscore the value of genomic surveillance in understanding zoonotic TB transmission at the human-livestock interface and its role in informing effective control strategies.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Zoonotic tuberculosis ; Mycobacterium bovis ; Mycobacterium caprae ; Whole genome sequencing ; Genomic epidemiology ; Cattle ; Goat ; Small ruminant
Published in:	One Health, Vol. 20 (february 2025) , ISSN 2352-7714

DOI: 10.1016/j.onehlt.2025.100993
PMID: 40035021

5 p, 1.6 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Centre de Recerca en Sanitat Animal (CReSA-IRTA)
Articles > Research articles
Articles > Published articles