Retinal Microperimetry as a Novel Tool for Early Detection of Subclinical Cognitive Dysfunction and Brain Damage in Type 1 Diabetes : A Pilot Study
Mateu-Salat, Manel (Institut de Recerca Sant Pau)
Stanton-Yonge, N. (Hospital General de Granollers)
Sampedro, Frederic (Institut de Recerca Sant Pau)
Vela, J. I (Institut de Recerca Sant Pau)
Díaz Cascajosa, Jesús (Institut de Recerca Sant Pau)
Safont Pérez, Eva (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Rego-Lorca, Daniela (Institut de Recerca Sant Pau)
Chico Ballesteros, Ana (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona

Data:	2025
Resum:	Context: Retinal microperimetry (MPR) is a non-invasive method that measures retinal light sensitivity (RS) and gaze fixation stability (GFS). MPR has been described as a marker of cognitive impairment in people with Type 2 diabetes, but it has never been assessed in people with Type 1 diabetes (T1D). Our group described subclinical cognitive alterations, structural brain differences, and increased levels of light chain neurofilament (NfL) in people with T1D and impaired awareness of hypoglycaemia. Objective: To measure RS and GFS using MPR in individuals with T1D and evaluate its correlation with neuropsychological assessment, plasma NfL levels and CGM-derived glucometric parameters. Secondary objectives: to evaluate the possible differences of RS and GFS in people with T1D depending on hypoglycaemia awareness. Design, Setting and Participants: Pilot observational study, people with T1D without clinical cognitive impairment, moderate-severe retinopathy or glaucoma. MPR was performed with MAIA3. Results: A total of 30 subjects were studied: 40% women, age 58 ± 11 years; T1D duration 31 ± 9 years, mild retinopathy 33%. RS was 27. 5 dB (26. 1-28. 3) and GFS(%) 97. 6% (93. 5%-99. 5%). We found a correlation between RS and memory alteration tests (p = 0. 016) and between GFS(%) and a composite of attention and executive neuropsychological tests (p = 0. 025). An inverse correlation between GFS and time below range was found. No correlation was found with NfL. Conclusion: This first exploratory study in people with T1D supports the potential utility of MPR as a screening tool for subclinical neurocognitive alterations in this population.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Brain damage ; Cognitive dysfunction ; Hypoglycaemia ; Microperimetry ; Type 1 diabetes
Publicat a:	Endocrinology, Diabetes and Metabolism, Vol. 8 Núm. 1 (january 2025) , p. e70018, ISSN 2398-9238

DOI: 10.1002/edm2.70018
PMID: 39707866

8 p, 299.9 KB

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