A re-assessment of the value of markers of corticosteroid contact allergy in the Spanish baseline series : Clobetasol propionate in the spotlight
Mercader-García, Pedro (Hospital General Universitario Morales Meseguer (Múrcia))
Silvestre Salvador, Juan Francisco (Zuwe Hofpoort Hospital)
Navarro-Triviño, Francisco José (Hospital Universitario San Cecilio (Granada))
Giménez-Arnau, Ana M. 1961- (Institut Hospital del Mar d'Investigacions Mèdiques)
Pastor-Nieto, María Antonia (Hospital Universitario Fundación Jiménez Díaz)
Córdoba-Guijarro, Susana (Hospital Universitario de Fuenlabrada ( Madrid))
Melé Ninot, Gemma (Hospital Universitari Sagrat Cor (Barcelona, Catalunya))
Tous Romero, Fátima (Hospital General Universitario 12 de Octubre)
González Pérez, Ricardo (Arabako Unibertsitate Ospitalea (Vitoria, País Basc))
Ruiz González, Inmaculada (Complejo Asistencial Universitario de León)
Sánchez-Pérez, Javier (Hospital Universitario de la Princesa (Madrid))
Gatica-Ortega, María Elena (Complejo Hospitalario de Toledo)
Sánchez-Pedreño, Paloma (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Miquel Miquel, Francisco Javier (Hospital Arnau de Vilanova (València))
Ortiz-Frutos, FJ. (Hospital General Universitario 12 de Octubre)
Carrascosa, José Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Serra-Baldrich, E. (Institut de Recerca Sant Pau)
Sanz-Sánchez, Tatiana (Hospital Universitario Infanta Sofía)
Soria-Aledo, V. (Hospital General Universitario Morales Meseguer (Múrcia))
Carrillo, Andres (Hospital General Universitario Morales Meseguer (Múrcia))
Borrego, Leopoldo (Complejo Hospitalario Universitario Insular Materno Infantil (Las Palmas de Gran Canaria))

Date:	2024
Abstract:	Background: Budesonide and tixocortol pivalate as markers of contact allergy to corticosteroids have been questioned, as they are not able to detect a significant percentage of allergic patients. Objectives: To investigate the potential role of clobetasol propionate in enhancing corticosteroid sensitisation detection. Methods: Between January 2022 and December 2023, patients who attended centres involved in the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy were tested with an extended baseline series that included budesonide, tixocortol pivalate, clobetasol propionate 0. 1% in ethanol and 1% in petrolatum. Results: A total of 4338 patients were tested. Twenty-four patients were allergic to budesonide (0. 55%, 95% CI: 0. 37-0. 82); nine patients were allergic to tixocortol pivalate (0. 21%, 95% CI: 0. 11-0. 39); and 23 patients were allergic to clobetasol (0. 53%, 95% CI: 0. 35-0. 79). Only four of those patients allergic to clobetasol were detected by budesonide and one by tixocortol pivalate. No significant differences in the number of positive tests were found between clobetasol in petrolatum or ethanol. Conclusions: In Spain budesonide remains the main corticosteroid allergy marker whereas the role of tixocortol pivalate is questionable. The addition of clobetasol propionate to the Spanish baseline series would improve the ability to detect patients allergic to corticosteroids.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Budesonide ; Clobetasol propionate ; Contact dermatitis ; Tixocortol pivalate
Published in:	Contact Dermatitis, Vol. 91 Núm. 3 (September 2024) , p. 228-236, ISSN 1600-0536

DOI: 10.1111/cod.14639

9 p, 2.0 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles