adhesiomeR : a tool for Escherichia coli adhesin classification and analysis
Sidorczuk, Katarzyna (Brandenburg University of Technology. Institute for Biotechnology)
Burdukiewicz, Michał (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Cerk, Klara (Norwich Research Park. Earlham Institute)
Fritscher, Joachim (Norwich Research Park. Earlham Institute)
Kingsley, Robert A. (University of East Anglia. Department of Biological Sciences)
Schierack, Peter (Brandenburg University of Technology. Institute for Biotechnology)
Hildebrand, Falk (Norwich Research Park. Earlham Institute)
Kolenda, Rafał (Wrocław University of Environmental and Life Sciences. Department of Biochemistry and Molecular Biology)

Date:	2024
Abstract:	Adhesins are crucial factors in the virulence of bacterial pathogens such as Escherichia coli. However, to date no resources have been dedicated to the detailed analysis of E. coli adhesins. Here, we provide adhesiomeR software that enables characterization of the complete adhesin repertoire, termed the adhesiome. AdhesiomeR incorporates the most comprehensive database of E. coli adhesins and facilitates an extensive analysis of adhesiome. We demonstrate that adhesiomeR achieves 98% accuracy when compared with experimental analyses. Based on analysis of 15,000 E. coli genomes, we define novel adhesiome profiles and clusters, providing a nomenclature for a unified comparison of E. coli adhesiomes.
Grants:	European Commission 948219
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Escherichia coli ; Adhesins ; Adhesiome ; Fimbriae ; Adhesion ; Pathotype ; Virulence factor
Published in:	BMC genomics, Vol. 25 (June 2024) , art. 609, ISSN 1471-2164

DOI: 10.1186/s12864-024-10525-6
PMID: 38886681

10 p, 1.9 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles