Psychological profiles associated with mental, cognitive and brain health in middle-aged and older adults
Bartrés-Faz, David (Institut Germans Trias i Pujol. Institut Guttmann)
Demnitz-King, H. (University College London)
Cabello-Toscano, María (Institut Germans Trias i Pujol. Institut Guttmann)
Vaqué-Alcázar, Lídia (Institut de Recerca Sant Pau)
Saunders, R. (University College London)
Touron, E. (Normandie Université)
Cattaneo, Gabriele (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Gonneaud, J. (Normandie Université)
Klimecki, O. (Clinical Psychology)
Bargalló, Núria (Hospital Clínic i Provincial de Barcelona)
Solana-Sánchez, Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Tormos, J.M. (Universidad Católica de Valencia)
Chételat, G. (Normandie Université)
Pascual-Leone, Á. (Harvard Medical School)
Marchant, N.L. (University College London)
Wirth, M. (German Center for Neurodegenerative Diseases (DZNE))
Whitfield, T. (University College London)
Walker, Z. (Essex Partnership University NHS Foundation Trust)
Wallet, C. (Institut National de la Santé et de la Recherche Médicale)
Vuilleumier, P. (University of Geneva)
Schlosser, M. (University of Geneva)
Smith, Rhonda (Minerva Health & Care Communications Ltd)
Smagghe, D. (Inserm Transfert)
Schimmer, C. (Carré International)
Schild, A.K. (University of Cologne)
Salmon, E. (University of Liège)
Rauchs, G. (Université de Caen-Normandie)
Quillard, A. (Normandie Université)
Poisnel, G. (Université de Caen-Normandie)
Ourry, V. (Normandie Université)
Molinuevo, José Luis (Institut Hospital del Mar d'Investigacions Mèdiques)
Michel, L. (Haute Autorité de Santé)
Meiberth, D. (University of Cologne)
Mezenge, F. (Normandie Université)
Lutz, A. (Lyon University)
Lefranc, V. (Normandie Université)
Landeau, B. (Normandie Université)
Kuhn, E. (Normandie Université)
Krolak-Salmon, P. (Hospices Civils de Lyon)
Jessen, Frank (University of Cologne)
Goldet, K. (Hospices Civils de Lyon)
Frison, E. (Centre Hospitalier Universitaire Bordeaux)
Ferrand Devouge, E. (Rouen University Hospital (França))
Delarue, M. (Normandie Université)
De La Sayette, V. (CHU de Caen)
Dautricourt, S. (Normandie Université)
Coll-Padros, Nina (Hospital Clínic i Provincial de Barcelona)
Collette, F. (Fund for Scientific Research FNRS)
Chocat, A. (Normandie Université)
Baez Lugo, S. (University of Geneva)
Bachelet, R. (Hospices Civils de Lyon)
André, C. (Normandie Université)
Universitat Autònoma de Barcelona

Date:	2025
Abstract:	Psychological characteristics are associated with varying dementia risk and protective factors. To determine whether these characteristics aggregate into psychological profiles and whether these profiles differentially relate to aging health, we conducted a cross-sectional investigation in two independent middle-aged (51. 4 ± 7. 0 years (mean ± s. d. ); N = 750) and older adult (71. 1 ± 5. 9 years; N = 282) cohorts, supplemented by longitudinal analyses in the former. Using a person-centered approach, three profiles emerged in both cohorts: those with low protective characteristics (profile 1), high risk characteristics (profile 2) and well-balanced characteristics (profile 3). Profile 1 showed the worst objective cognition in older age and middle age (at follow-up), and most rapid cortical thinning. Profile 2 exhibited the worst mental health symptomology and lowest sleep quality in both older age and middle age. We identified profile-dependent divergent patterns of associations that may suggest two distinct paths for mental, cognitive and brain health, emphasizing the need for comprehensive psychological assessments in dementia prevention research to identify groups for more personalized behavior-change strategies.
Grants:	Agencia Estatal de Investigación PID2022-139298OA-C22
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Alzheimer's disease ; Psychology
Published in:	Nature Mental Health, Vol. 3 Núm. 1 (january 2025) , p. 92-103, ISSN 2731-6076

DOI: 10.1038/s44220-024-00361-8

16 p, 2.2 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles