Comparison of clinical measures of motor function with a Holter monitor in Parkinson's disease
Pérez-López, C. (Consorci Sanitari de l'Alt Penedès i Garraf)
Caballol, Nuria (Hospital de Sant Joan Despí Moisès Broggi)
Buongiorno, M. (Hospital Universitari Mútua Terrassa (Barcelona))
Ávila Rivera, Maria A. (Hospital General de l'Hospitalet (Barcelona))
Ariztegui, N.L. (Hospital Universitario de Toledo)
López-Manzanares, L. (Hospital Universitario de la Princesa (Madrid))
Hernández-Vara, Jorge (Hospital Universitari Vall d'Hebron)
Rusiñol, À.B. (Hospital Quirón-Teknon)
Gironell, Alexandre (Institut de Recerca Sant Pau)
Saúco, M.Á. (Hospital General Universitario de Elche)
Gomez, E.F. (Hospital Sant Camil (Barcelona))
Pérez-Martínez, D.A. (Hospital Universitario)
Arroyo, S.E. (Hospital de Tortosa Verge de la Cinta (Tarragona))
Martínez, S.M. (Hospital General Universitari d'Alacant)
Mir, Pablo (Universidad de Sevilla)
Salom Juan, J.M. (Hospital Clínic Universitari (València))
Martínez-Castrillo, J.C. (Hospital Universitario Ramón y Cajal (Madrid))
Rodríguez-Molinero, A. (Consorci Sanitari de l'Alt Penedès i Garraf)
Universitat Autònoma de Barcelona

Data:	2025
Resum:	Background: Parkinson's disease (PD) is a significant global health challenge, affecting millions worldwide. This sub-study aims to explore the potential of ambulatory monitoring devices in identifying disease severity and progression in patients. As part of the MOMOPA-EC clinical trial, 156 patients with moderate to severe PD underwent 435 assessments using clinical scales and ambulatory monitoring devices (Parkinson's Holter). This sub-study seeks to establish relations between parameters derived from Holter monitors and clinical severity measures to enhance personalized disease management strategies. Methods: In the MOMOPA-EC trial, 435 patient monitoring sessions were conducted, during which patients wore Parkinson's Holter monitors for a week before completing clinical assessments, including the Unified Parkinson's Disease Rating Scale (UPDRS), Parkinson's Disease Questionnaire (PDQ-39), and Freezing of Gait Questionnaire (FoG-Q). Results: The reports obtained during the monitoring of the patients were classified into three groups based on the greater or lesser gait fluidity (according to the measurements from the Parkinson's Holter). All clinical scales were significantly different in each of these groups, indicating that patients with lower stride fluidity had poorer outcomes across the different clinical scales. Conclusions: The findings of this study underscore the potential of Parkinson's Holters in providing objective data for personalized disease management in PD patients. Integrating such technologies into routine clinical practice could enhance patient care and treatment strategies by offering clinicians objective insights into both disease progression and therapeutic response.
Ajuts:	Instituto de Salud Carlos III DTS17/00195
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Automatic ambulatory monitoring ; Motor fluctuations ; Parkinson's disease ; Therapeutic adjustment ; Wearable sensors
Publicat a:	Clinical Parkinsonism and Related Disorders, Vol. 12 (january 2025) , p. 100325, ISSN 2590-1125

DOI: 10.1016/j.prdoa.2025.100325
PMID: 40329979

7 p, 1.1 MB

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