Association between the GMI/HbA1c ratio and preclinical carotid atherosclerosis in type 1 diabetes : impact of the fast-glycator phenotype across age groups
Puig-Jové, Carlos (Hospital Universitari MútuaTerrassa)
Viñals, Clara (Hospital Clínic i Provincial de Barcelona)
Conget, Ignacio (Hospital Clínic i Provincial de Barcelona)
Quirós, Carmen (Hospital Universitari MútuaTerrassa)
Vinagre, Irene (Hospital Clínic i Provincial de Barcelona)
Berrocal, B. (Hospital Universitari MútuaTerrassa)
Blanco-Carrasco, Antonio-Jesús (Hospital Clínic i Provincial de Barcelona)
Granados, Montserrat (Hospital Clínic i Provincial de Barcelona)
Mesa, Alex (Institut de Recerca Sant Pau)
Serés-Noriega, Tonet (Hospital Clínic i Provincial de Barcelona)
Giménez, Marga (Hospital Clínic i Provincial de Barcelona)
Perea, Verónica (Hospital Universitari MútuaTerrassa)
Amor Fernández, Antonio J. (Hospital Clínic i Provincial de Barcelona)
Universitat Autònoma de Barcelona

Data:	2025
Resum:	Background: Since the arrival of continuous glucose monitoring (CGM), the relationship between the glucose management indicator (GMI) and HbA1c has been a topic of considerable interest in diabetes research. This study aims to explore the association between the GMI/HbA1c ratio and the presence of preclinical carotid atherosclerosis in type 1 diabetes (T1D). Methods: Individuals with T1D and no prior history of cardiovascular disease were recruited from two centers. Carotid ultrasonography was performed using a standardized protocol and carotid plaques were defined as intima-media thickness ≥ 1. 5 mm. CGM-derived data were collected from a 14-day report. A GMI/HbA1c ratio < 0. 90 was selected to identify "fast-glycator" phenotype. Results: A total of 584 participants were included (319 women, 54. 6%), with a mean age of 48. 8 ± 10. 7 years and a mean diabetes duration of 27. 5 ± 11. 4 years. Carotid plaques were present in 231 subjects (39. 6%). Approximately 43. 7% and 13. 4% of participants showed absolute differences of ≥ 0. 5 and ≥ 1. 0 between 14-day GMI and HbA1c, respectively. Among patients ≥ 48 years, the fast-glycator phenotype was independently associated with presence of plaques (OR 2. 27, 95%CI: 1. 06-4. 87), even after adjusting for non-specific and T1D-specific risk factors and statin treatment. No significant association was observed in younger subjects (p for interaction < 0. 05). Conclusions: Fast-glycator phenotype is independently associated with atherosclerosis in T1D individuals aged ≥ 48 years, suggesting an age-related increase in the glycation risk. These findings highlight the potential of the GMI/HbA1c ratio for cardiovascular risk stratification in this population.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Carotid atherosclerosis ; Glucose Management Indicator ; Hemoglobin glycation ; Type 1 diabetes
Publicat a:	Cardiovascular diabetology, Vol. 24 Núm. 1 (december 2025) , p. 75, ISSN 1475-2840

DOI: 10.1186/s12933-025-02637-4
PMID: 39953520

12 p, 1.5 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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