Impact of PSMA-PET/CT on Radiotherapy Decisions : Is There a Clinical Benefit?
Gomis-Sellés, E. (Hospital Clínic i Provincial de Barcelona)
Maldonado, A. (Hospital Universitario La Luz)
Gaztañaga, M. (GenesisCare Hospital Universitario Vithas Madrid La Milagrosa)
Vera, V. (Hospital Universitario de Badajoz)
Ajulia, O. (Hospital Universitario Ramón y Cajal (Madrid))
Sancho-Pardo, Gemma (Institut de Recerca Sant Pau)
Siva, S. (Peter MacCallum Cancer Centre)
Lopez-Campos, F. (Hospital Universitario Ramón y Cajal (Madrid))
Couñago, Felipe (Universidad Europea de Madrid)
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2025
Abstract:	Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA-PET/CT) has emerged as a game-changing imaging modality in prostate cancer, offering superior sensitivity and specificity compared to conventional imaging techniques. Its increasing adoption has significantly influenced radiotherapy decision-making, yet its true clinical impact remains under investigation. This narrative review explores the role of PSMA-PET/CT in guiding radiotherapy decisions across different clinical scenarios, from primary treatment planning to biochemical recurrence and oligometastatic disease. We assess its impact on target delineation, treatment modifications, and overall patient management while addressing existing knowledge gaps.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	PET-based treatment planning ; PSMA ; Androgen deprivation therapy ; Biochemical recurrence ; Metastasis-directed therapy ; Prostate cancer ; Radiotherapy ; Salvage radiotherapy ; Target volume delineation
Published in:	Cancers, Vol. 17 Núm. 8 (april 2025) , p. 1350, ISSN 2072-6694

DOI: 10.3390/cancers17081350
PMID: 40282526

24 p, 2.2 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles