Negative symptoms and sex differences in first episode schizophrenia : What's their role in the functional outcome? A longitudinal study
Amoretti, Silvia (University of Perugia)
Mezquida, Gisela (Hospital Clínic i Provincial de Barcelona)
Verdolini, Norma (Hospital Clínic i Provincial de Barcelona)
Bioque, Miquel (Hospital Clínic i Provincial de Barcelona)
Sánchez-Torres, A.M. (Complejo Hospitalario de Navarra)
Pina-Camacho, Laura (Hospital General Universitario Gregorio Marañón)
Zorrilla, Iñaki (Instituto de Salud Carlos III)
Trabsa, Amira (Hospital del Mar (Barcelona, Catalunya))
Rodriguez-Jimenez, Roberto (Universidad Complutense de Madrid)
Corripio, Iluminada (Institut de Recerca Sant Pau)
Sarró, Salvador (FIDMAG Germanes Hospitalàries Research Foundation)
Ibañez, A. (Hospital Universitario Ramón y Cajal (Madrid))
Usall, J. (Parc Sanitari Sant Joan de Déu)
Segarra, R. (Hospital Universitario de Cruces - Osakidetza)
Vieta, Eduard (Hospital Clínic i Provincial de Barcelona)
Roberto, Natalia (Hospital Clínic i Provincial de Barcelona)
Ramos-Quiroga, Josep Antoni (Hospital Universitari Vall d'Hebron)
Tortorella, Alfonso (Hospital Universitari Vall d'Hebron)
Menculini, G. (Hospital Universitari Vall d'Hebron)
Parellada, M. (Hospital General Universitario Gregorio Marañón)
González-Pinto, Ana (Instituto de Salud Carlos III)
Berrocoso, E. (Hospital Universitario Puerta del Mar (Cadis, Andalusia))
Bernardo, Miquel (Hospital Clínic i Provincial de Barcelona)
Forte, Maria Florencia (Hospital Clínic i Provincial de Barcelona)
Serra-Navarro, Maria (Hospital Clínic i Provincial de Barcelona)
Alonso-Solís, Anna (Institut de Recerca Sant Pau)
Grasa, Eva (Institut de Recerca Sant Pau)
Corres, E.G. (Universidad del País Vasco)
Fernandez Sevillano, J. (Universidad del País Vasco)
Toll Abelló, Agustí (Hospital del Mar (Barcelona, Catalunya))
Martínez Sadurní, Laura (Hospital del Mar (Barcelona, Catalunya))
Nuñez-Doyle, A. (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12))
Sanchez-Pastor, L. (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12))
Pomarol-Clotet, E. (Instituto de Salud Carlos III)
Guerrero-Pedraza, A. (Hospital Benito Menni)
Butjosa Molines, Anna (Hospital Infanto-juvenil Sant Joan de Déu)
Pardo, M. (Hospital Infanto-juvenil Sant Joan de Déu)
López-Ilundain, J.M. (Complejo Hospitalario de Navarra)
Ribeiro, M. (Complejo Hospitalario de Navarra)
Saiz-Ruiz, J. (Universidad de Alcalá)
Escarti, M.J. (Fundación Investigación Hospital Clínico de Valencia)
Contreras, Fernando (Hospital Universitari de Bellvitge)
De-la-Cámara, Concepción (Universidad de Zaragoza)
Zabala Rabadán, A. (Instituto de Salud Carlos III)
Portilla, M.P. (Centro Médico de Asturias)
Cuesta, Manuel J. (Complejo Hospitalario de Navarra)
León-Quismondo, Leticia (Hospital Universitario Ramón y Cajal (Madrid))
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2025
Abstract:	Introduction: Negative symptoms (NS) include asociality, avolition, anhedonia, alogia, and blunted affect and are linked to poor prognosis. It has been suggested that they reflect two different factors: diminished expression (EXP) (blunted affect and alogia) and amotivation/pleasure (MAP) (anhedonia, avolition, asociality). The aim of this article was to examine potential sex differences among first-episode schizophrenia (FES) patients and analyze sex-related predictors of two NS symptoms factors (EXP and MAP) and functional outcome. Material and methods: Two hundred and twenty-three FES (71 females and 152 males) were included and evaluated at baseline, six-months and one-year. Repeated measures ANOVA was used to examine the effects of time and sex on NS and a multiple linear regression backward elimination was performed to predict NS factors (MAP-EXP) and functioning. Results: Females showed fewer NS (p = 0. 031; Cohen's d = -0. 312), especially those related to EXP (p = 0. 024; Cohen's d = -0. 326) rather than MAP (p = 0. 086), than males. In both male and female group, worse premorbid adjustment and higher depressive symptoms made a significant contribution to the presence of higher deficits in EXP at one-year follow-up, while positive and depressive symptoms predicted alterations in MAP. Finally, in females, lower deficits in MAP and better premorbid adjustment predicted better functioning at one-year follow-up (R = 0. 494; p < 0. 001), while only higher deficits in MAP predicted worse functioning in males (R = 0. 088; p = 0. 012). Conclusions: Slightly sex differences have been found in this study. Our results lead us to consider that early interventions of NS, especially those focusing on motivation and pleasure symptoms, could improve functional outcomes.
Grants:	Instituto de Salud Carlos III PI20/01066 Ministerio de Ciencia e Innovación PI11/00325 Ministerio de Economía y Competitividad PI14/00612 Generalitat de Catalunya2021 SGR 1358 Generalitat de CatalunyaSLT006/17/00357 Instituto de Salud Carlos IIIPI21/00787 Instituto de Salud Carlos IIIPI18/00805
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	First-episode of psychosis ; Functional outcome ; Negative symptoms ; Schizophrenia ; Sex
Published in:	Spanish journal of psychiatry and mental health, Vol. 18 Núm. 2 (january 2025) , p. 91-99, ISSN 2950-2853

DOI: 10.1016/j.sjpmh.2023.04.001
PMID: 38591832

9 p, 255.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles