TMA-93 (binding by images) : Cutoffs optimization based on Alzheimer's disease biomarkers
Arriola Infante, José Enrique (Institut de Recerca Sant Pau)
García-Roldán, E. (Hospital Universitari Verge del Rocío)
García-Solís, D. (Hospital Universitari Verge del Rocío)
Marín-Cabañas, A.M. (Hospital Universitari Verge del Rocío)
Luque-Tirado, A. (Hospital Universitari Verge del Rocío)
Almodóvar-Sierra, Ángela (Hospital Universitari Verge del Rocío)
Sánchez-Arjona, M.B. (Hospital Universitari Verge del Rocío)
Maillet, D. (Hôpital Saint-Louis (AP-HP))
Franco-Macías, Emilio (Hospital Universitari Verge del Rocío)
Universitat Autònoma de Barcelona. Departament de Medicina

Data:	2025
Resum:	Background: With the arrival of new disease-modifying treatments for Alzheimer's disease (AD), feasible cognitive tests, also for illiterate patients, are needed to screen those requiring deeper evaluation among individuals presenting with memory complaints. The TMA-93, a brief binding memory test, has proven useful for diagnosing early AD, and is supported by normative data that accounts for age and cognitive reserve. Objective: To compare the sensitivity of different TMA-93 cutoffs in detecting AD pathology. Methods: A retrospective analysis was performed on a biobank sample of patients with confirmed AD pathology via amyloid PET or cerebrospinal fluid (CSF) biomarkers. The sensitivity of six TMA-93 cutoffs was evaluated: the 10th, 15th, and 20th percentiles based on traditional norming (TN) and regression-based norming (RBN). False negatives (FN) characteristics were also analyzed. Results: A total of 270 AD-positive patients (96 by amyloid-PET, 174 by CSF biomarkers) were included, comprising 224 with mild cognitive impairment and 46 with mild dementia. The 15th percentile using RBN demonstrated substantial sensitivity (80. 4%), higher than that of the 10th percentile, and also provided a more uniform distribution across normative groups compared to the TN approach. Higher global cognition (Mini-Mental State Examination score) and, in patients over 70, lower cognitive reserve (Cognitive Reserve Questionnaire), were linked to a greater likelihood of FN results. Conclusions: The 15th percentile cutoff based on RBN, accounting for age and cognitive reserve, improves sensitivity for detecting AD pathology, making it a valuable screening tool for memory complaints. Future normative data from biomarker-negative subjects may enhance the sensitivity of cognitive tests.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Alzheimer's disease ; Biomarkers ; Cognition ; Cognitive reserve ; Memory ; Neuropsychological tests ; Normative data
Publicat a:	Journal of Alzheimer's disease, Vol. 105 Núm. 1 (may 2025) , p. 65-76, ISSN 1875-8908

DOI: 10.1177/13872877251325759
PMID: 40116687

12 p, 1.4 MB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
Articles > Articles de recerca
Articles > Articles publicats