| Data: |
2025 |
| Resum: |
Background and objective: Dysphagia at time of diagnosis suggests atypical parkinsonism instead Parkinson's disease (PD). Our aim was to analyze the frequency of dysphagia in patients with early PD comparing with a control group and to identify related factors. Patients and methods: Patients with early PD (≤ 2 years from symptoms onset) who were recruited from January/2016 to November/2017 (baseline visit; V0) and evaluated annually for 5 years from the Spanish cohort COPPADIS were included in this prospective study. Controls were assessed at baseline and at 2-, 4-, and 5-year follow-up. Dysphagia was defined as a score ≥ 1 in the item 20 of the Non-Motor Symptoms Scale (NMSS). Results: Dysphagia was more frequent at baseline in PD patients (19. 6% [36/184]; 62. 3 ± 8. 3 years old; 56. 8% males) than in controls (5. 3% [11/206]; 60. 9 ± 8. 3 years old; 50% males) (p < 0. 0001) and in all visits as well (p < 0. 0001). A worse quality of sleep (Parkinson's Disease Sleep Scale; OR = 0. 974; p = 0. 005), a greater impulse-control behavior (ICB) (Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale; OR = 1. 066; p = 0. 014), and non-motor symptoms burden (Non-Motor Symptoms Scale; OR = 1. 016; p = 0. 021) were independent factors associated with dysphagia at baseline. In those subjects with dysphagia, no differences were observed between patients and controls in the mean NMSS-item 20 overtime, and it didn't change throughout the follow-up. Conclusion: Dysphagia was frequent in early PD patients compared to controls. However, it was minor and did not progress over time. Sleep, ICB, and non-motor symptoms burden were related to dysphagia. |
| Ajuts: |
Instituto de Salud Carlos III PI18/01898
Ministerio de Economía y Competitividad PI16/01575
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| Drets: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: |
Anglès |
| Document: |
Article ; recerca ; Versió publicada |
| Matèria: |
Cohort ;
Dysphagia ;
Early ;
Impulse control disorder ;
Non-motor symptoms ;
Parkinson's disease |
| Publicat a: |
Neurological sciences, Vol. 46 Núm. 6 (june 2025) , p. 2637-2653, ISSN 1590-3478 |
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