Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain : A Multicenter Study
Pérez-Sáez, María José (Institut Hospital del Mar d'Investigacions Mèdiques)
Melilli, Edoardo (Hospital Universitari de Bellvitge)
Arias-Guillén, Marta (Hospital Clínic i Provincial de Barcelona)
Franco, Antonio (Hospital General Universitario)
Molina Molina, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Facundo, Carme (Institut de Recerca Sant Pau)
López, Verónica (Universidad de Málaga)
Mazuecos, Auxiliadora (Hospital Universitario Puerta del Mar (Cadis, Andalusia))
Cabello Pelegrín, Sheila (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
González García, María Elena (Hospital Universitario La Paz (Madrid))
Suárez, María Luisa (Hospital Universitario Central De Asturias (Astúries))
Auyanet, Ingrid (Complejo Hospitalario Insular de Gran Canaria)
Espi, Jordi (Hospital Universitari i Politècnic La Fe (València))
Ruiz, Juan Carlos (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Galeano Alvarez, Cristina (Hospital Universitario Ramón y Cajal (Madrid))
Artamendi, Marta (Hospital San Pedro de Alcántara)
Rodríguez-Ferrero, María Luisa (Hospital General Universitario Gregorio Marañón)
Portolés, José María (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Calvo, Marta (Hospital Clínico San Carlos (Madrid))
Mendiluce, Alicia (Hospital Clínico Universitario de Valladolid)
Macía, Manuel (Hospital Virgen de la Candelaria)
de Teresa, Javier (Hospital Universitario Virgen de las Nieves (Granada))
Soriano Cabrera, Sagrario (Hospital Universitario Reina Sofía (Còrdova, Espanya))
Tabernero, Guadalupe (Hospital Universitario de Salamanca)
de la Vara, Lourdes (Complejo Hospitalario General Universitario de Albacete)
Martínez, Rafael 1965- (Sandoz Farmacéutica SA.)
Pascual, Julio (Hospital 12 de Octubre (Madrid))
Rodríguez-Mañas, Leocadio (Hospital Universitario de Getafe (Madrid))
Gutiérrez-Dalmau, Alex (Hospital Universitario Miguel Servet (Saragossa))
Moreso, Francesc (Hospital Universitari Vall d'Hebron)
Martínez, Rocío (Hospital Universitario Infanta Cristina)
Sancho Calabuig, Asunción (Hospital Universitari Doctor Peset (València))
Polanco, Natalia (Hospital 12 de Octubre (Madrid))
García Falcón, Teresa (Complejo Hospitalario Universitario de A Coruña)
Auxiliadora Santana, María (Hospital Universitario de Cruces (Barakaldo, País Basc))
Martin-Moreno, Paloma Leticia (Clínica Universidad de Navarra)
Arhda, Nisrine (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Pérez Tamajón, María Lourdes (Hospital Universitario de Canarias (La Laguna))
Gascó, Blanca (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Ramos, Ana María (Hospital Universitario Fundación Jiménez Díaz)
Montero de Espinosa, Enrique (Sandoz Farmacéutica SA)
Zalve, José Luis (Sandoz Farmacéutica SA)
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2025
Abstract:	Frailty is a frequent condition among kidney transplant candidates (KTc) that confers poor outcomes after transplantation. We aimed to establish frailty prevalence in a representative sample of KTc in Spain. We conducted a multicenter cross-sectional study including 1194 KTc ≥50 years. Frailty was assessed by the FRAIL scale. Mean age was 64. 2 years; 38. 4% were female. Median Charlson comorbidity index (CCI) was 6 [4-7] and the total number of medications was 9 [7-12]. We found that 8. 2% of patients were frail and 41. 5% were pre-frail. Frailty was more frequent among females (60. 2% of frail vs. 32. 8% of robust; p < 0. 001), hemodialysis patients (74. 5% of frail vs. 67. 1% of robust; p = 0. 02), and those with a high burden of disease (54. 6% of frail patients with CCI >6 vs. 29. 3% of robust; p < 0. 001). The multivariable analysis confirmed that frailty was associated with the female sex (OR 3. 9 [2. 5-6. 2]); higher CCI (>6 OR 2. 9 [1. 6-54]); and the number of medications (OR -per medication- 1. 13 [1. 07-1. 2]). Almost 50% of KTc in Spain are pre-frail or frail. Frailty is more prevalent between women and patients with high comorbidity burden. Identifying those candidates at risk is essential to establish risks and implement strategies to minimize them.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	FRAIL ; Candidate ; Frailty ; Kidney transplant ; Waiting list
Published in:	Transplant International, Vol. 38 (2025) , art. 14098, ISSN 1432-2277

DOI: 10.3389/ti.2025.14098
PMID: 40630784

9 p, 1.1 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles