Neural and biomarker correlates of the Parkinson's Disease-Cognitive Rating Scale in Huntington's disease
Martínez-Horta, Saul (Institut de Recerca Sant Pau)
Puig-Davi, Arnau (Institut de Recerca Sant Pau)
Sampedro, Frederic (Hospital Universitari Vall d'Hebron)
Pérez-Pérez, Jesús (Institut de Recerca Sant Pau)
Franch-Martí, Carla (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Olmedo-Saura, Gonzalo (Institut de Recerca Sant Pau)
Rivas Asensio, Elisa (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Vázquez-Oliver, Anna (Institut de Recerca Sant Pau)
Pérez-Carasol, Laura (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Horta-Barba, Andrea (Institut de Recerca Sant Pau)
Pagonabarraga Mora, Javier (Institut de Recerca Sant Pau)
Kulisevsky, Jaime (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2025
Abstract:	Cognitive decline is a core feature of Huntington's disease (HD), often preceding motor symptoms and progressing with disease severity. While several neuropsychological tests track cognitive changes, few studies have examined the biological correlates of brief screening tools adapted for HD. This study investigates the neuroanatomical and fluid biomarker correlates of performance on the Parkinson's Disease-Cognitive Rating Scale (PD-CRS), aiming to validate it as a clinically and biologically grounded tool for cognitive assessment in HD. Fifty-two symptomatic gene-expansion carriers (CAG.
Grants:	Instituto de Salud Carlos III PI21/01758
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Huntington's disease ; PD-CRS ; Cognitive assessment ; MRI ; Neuropsychology
Published in:	Neuroimage. Reports, Vol. 6 (December 2025) , art. 100311, ISSN 2666-9560

DOI: 10.1016/j.ynirp.2025.100311
PMID: 41492395

8 p, 2.7 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles