PD-L1 and the risk of bacterial infection in patients with chronic liver diseases : An international multicohort study
Juanola, Adrià (Hospital Clínic i Provincial de Barcelona)
Mezzano, Gabriel (Universidad de los Andes (Xile))
Pose, Elisa (Hospital Clínic i Provincial de Barcelona)
Moreta, Maria J. (Hospital Clínic i Provincial de Barcelona)
Incicco, Simone (University and Hospital of Padova)
Gagliardi, Roberta (University and Hospital of Padova)
Johansen, Stine (University of Southern Denmark)
Torp, Nikolaj (University of Southern Denmark)
Israelsen, Mads (University of Southern Denmark)
Jiménez-Esquivel, Natalia (Hospital Clínic i Provincial de Barcelona)
Castillo-Iturra, Joaquin (Hospital Clínic i Provincial de Barcelona)
Ribera Salas, Jordi (Hospital Clínic i Provincial de Barcelona)
Gratacós-Ginès, Jordi (Hospital Clínic i Provincial de Barcelona)
Soria, Anna (Hospital Clínic i Provincial de Barcelona)
Cárdenas, Andrés (Hospital Clínic i Provincial de Barcelona)
Pérez-Guasch, Martina (Hospital Clínic i Provincial de Barcelona)
Cervera, Marta (Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain)
Nadal, Ruth (Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain)
Herms, Queralt (Hospital Clínic i Provincial de Barcelona)
Tonon, Marta (University and Hospital of Padova)
Hansen, Torben (University of Copenhagen)
Stankevic, Evelina (University of Copenhagen)
Huang, Yun (University of Copenhagen)
Vargas Blasco, Víctor (Hospital Universitari Vall d'Hebron)
Zaccherini, Giacomo (IRCCS Azienda Ospedaliero-Universitaria di Bologna)
Alessandria, Carlo (University of Turin)
Uschner, Frank E. (University Hospital of Münster (Alemanya))
Beuers, Ulrich (Universiteit van Amsterdam)
Francoz, Claire (Centre de Recherche sur l'Inflammation, France)
Mookerjee, Rajeshwar P. (Aarhus University)
Laleman, Wim (UZ Leuven)
Solé Marcé, Cristina (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Bañares, Rafael (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Cuyàs, Berta (Institut de Recerca Sant Pau)
Ariza, Xavi (Hospital de Sant Joan Despí Moisès Broggi)
Coll, Mar (Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain)
Graupera, Isabel (Hospital Clínic i Provincial de Barcelona)
Fabrellas, Núria (Universitat de Barcelona)
Morales Ruiz, Manuel (Hospital Clínic i Provincial de Barcelona)
Thiele, Maja (University of Southern Denmark)
Krag, Aleksander (University of Southern Denmark)
Angeli, Paolo (University and Hospital of Padova)
Piano, Salvatore (University and Hospital of Padova)
Solà, Elsa (Stanford University School of Medicine)
Ginès, Pere (Hospital Clínic i Provincial de Barcelona)
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2025
Abstract:	Impaired phagocytic capacity due to activation of the PD-1/PD-L1 pathway has been implicated in the development of bacterial infections in patients with cirrhosis. Soluble PD-L1 (sPD-L1) is easily measurable in plasma and has been proposed as a biomarker of sepsis. In the current study, we aim to evaluate the role of sPD-L1 as a biomarker of bacterial infection development in patients with cirrhosis. Plasma samples from 995 patients with chronic liver disease grouped in three cohorts were analyzed: an initial cohort of 268 hospitalized patients with acute decompensated cirrhosis, 327 out-patients with non-acute decompensated cirrhosis and finally 400 patients with high-risk alcohol consumption, including all stages of liver fibrosis, from mild/no fibrosis to cirrhosis (F0-F4). The main outcomes of the study were development of bacterial infection and mortality. Patients who developed bacterial infections had higher median levels of sPD-L1 than those who did not (160 [IQR 116-221] vs. 136 [IQR 97-193] pg/ml, respectively, p value.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Liver cirrhosis ; Bacterial infection ; PD-L1 ; Biomarkers ; Decompensated cirrhosis ; Mortality
Published in:	JHEP Reports, Vol. 7 (September 2025) , art. 101597, ISSN 2589-5559

DOI: 10.1016/j.jhepr.2025.101597
PMID: 41321934

9 p, 904.2 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles