A Metagenomics Approach to Frailty in Patients With Cirrhosis Undergoing a Multifactorial Intervention
Vega-Abellaneda, Sara (Vall d'Hebron Institut de Recerca (VHIR))
Roman, Eva (Institut de Recerca Sant Pau)
Soler, Zaida (Vall d'Hebron Institut de Recerca (VHIR))
Rossi, Giacomo (University of Camerino)
Sánchez, Elisabet (Institut de Recerca Sant Pau)
Pons-Tarin, Marc (Vall d'Hebron Institut de Recerca (VHIR))
Laghi, Luca (Università di Bologna)
Kaur Gill, Naujot (Institut de Recerca Sant Pau)
Poca Sans, Maria (Institut de Recerca Sant Pau)
Cuyàs, Berta (Institut de Recerca Sant Pau)
Alvarado-Tapias, Edilmar (Institut de Recerca Sant Pau)
Manichanh, Chaysavanh (Vall d'Hebron Institut de Recerca (VHIR))
Soriano, German (Institut de Recerca Sant Pau)
Ortiz, M. Àngels (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Biagini, Lucia (University of Camerino)
Mengucci, Carlo (Università di Bologna)
Serrano-Gómez, Gerard (Vall d'Hebron Institut de Recerca (VHIR))
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2025
Abstract:	The relationship between frailty and gut microbiota has not been previously addressed in patients with cirrhosis. We studied by metagenomic shotgun sequencing the faecal microbiota composition associated with frailty in 29 patients with cirrhosis from a previous study (Román, Hepatol Commun 2024). Frail and prefrail patients were randomised to a multifactorial intervention (home exercise, branched-chain amino acids and a multistrain probiotic) or control for 12 months. We observed a positive correlation between the abundance of and the Liver frailty index (LFI), and between and gait speed. After the multifactorial intervention, LFI improved and the main changes in the microbiota composition were a decrease in the abundance of , and an increase in , and several species of Bifidobacterium. We conclude that frailty in patients with cirrhosis was associated with a distinct microbiome signature. After a long-term multifactorial intervention, frailty improved in parallel with changes in microbiome composition. Trial Registration: identifier: .
Grants:	Instituto de Salud Carlos III PI19/00275
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cirrhosis ; Exercise ; Frailty ; Microbiota ; Probiotics
Published in:	Liver international, Vol. 45 (November 2025) , art. e70418, ISSN 1478-3231

DOI: 10.1111/liv.70418
PMID: 41174950

4 p, 476.7 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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