Usefulness of the Heavy Menstrual Bleeding Diagnostic Tools SAMANTA Questionnaire and Heavy Menstrual Bleeding-Visual Analog Scale Tool for Iron Deficiency Screening : An Exploratory Analysis from the COLIBRI Study
Perelló Capo, Josep (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)
Estadella Tarriel, Josep (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)
Gich, Ignasi (Institut de Recerca Sant Pau)
Llurba, Elisa (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Calaf Alsina, Joaquim (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)
Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia

Date:	2025
Abstract:	The SAMANTA questionnaire and the Heavy Menstrual Bleeding-Visual Analog Scale (HMB-VAS) tool have been validated for diagnosing heavy menstrual bleeding (HMB). We assessed their value for screening iron deficiency (ID). Post hoc analysis of the prospective, randomized, phase 4 Cooper and Levonorgestrel Intrauterine Device (IUD) Barcelona Research Iniciative (COLIBRI) study, which assessed the bleeding profile of two intrauterine devices. We used information collected during the last follow-up visit (month 36): sociodemographics, hemoglobin/ferritin levels, SAMANTA questionnaire, HMB-VAS tool, and EuroQoL five-dimension five-level scores. The primary outcome was the accuracy of these diagnostic tools in identifying ID. We also assessed their relationship with EQ-5D-5L. We analyzed information from 57 women, 18 (31. 6%) and 14 (24. 6%) with HMB according to the SAMANTA questionnaire and the HMB-VAS tool, respectively. Ferritin levels showed better inverse correlation than hemoglobin with these HMB diagnostic tools' scores: r = -0. 539 and r = -0. 557, respectively, both p. < 0. 001. In women with HMB according to these tools, the ferritin threshold showing the best sensitivity and specificity to identify ID was <10 ng/mL with the SAMANTA questionnaire (71. 4% [Confidence Interval (CI) 95% 35. 2-93. 5] and 78% [CI 95% 65. 2-87. 7], respectively) and <15 ng/mL for the HMB-VAS tool (58. 3% [CI 95% 31. 2-87. 7] and 82. 2% [CI 95% 69. 2-91. 2], respectively). Only the EQ-VAS scores correlated inversely with the scores of both HMB diagnostic tools (r = -0. 308, p = 0. 02, and r = -0. 294, p = 0. 026, respectively). Conclusions: This exploratory analysis shows the SAMANTA questionnaire's good potential for ID screening. The scores of both HMB diagnostic tools correlated with the EQ-VAS, demonstrating their value in capturing the HMB impact on quality of life.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Heavy menstrual bleeding ; Iron deficiency ; Quality of life ; Screening ; Ferritin ; Performance
Published in:	Women's Health Reports, Vol. 6, Num. 1 (September 2025) , p. 1001-1009, ISSN 2688-4844

DOI: 10.1177/26884844251382731
PMID: 41142484

9 p, 1.4 MB

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