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Articles 16 records found  previous11 - 16  jump to record: Search took 0.00 seconds. 
11.
15 p, 11.4 MB Neuroprotective drug for nerve trauma revealed using artificial intelligence / Romeo-Guitart, David (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Forés Vineta, Joaquim (Hospital Clínic i Provincial de Barcelona) ; Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Valls, Raquel (Anaxomics Biotech.) ; Leiva-Rodríguez, Tatiana (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Galea, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències) ; González-Pérez, Francisco (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Petegnief, Valerie (Institut de Recerca Biomèdica de Lleida) ; Bosch i Merino, Assumpció (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Coma, Mireia (Anaxomics Biotech.) ; Mas, José Manuel (Anaxomics Biotech.) ; Casas Louzao, Caty (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Here we used a systems biology approach and artifcial intelligence to identify a neuroprotective agent for the treatment of peripheral nerve root avulsion. Based on accumulated knowledge of the neurodegenerative and neuroprotective processes that occur in motoneurons after root avulsion, we built up protein networks and converted them into mathematical models. [...]
2018 - 10.1038/s41598-018-19767-3
Scientific reports, Vol. 8 (2018) , art. 1879  
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12.
13 p, 3.4 MB Network-based proteomic approaches reveal the neurodegenerative, neuroprotective and pain-related mechanisms involved after retrograde axonal damage / Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Isus, Laura (Institut de Recerca Biomèdica de Lleida) ; Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Mancuso, Francesco M. (Vall d'Hebron Institut d'Oncologia) ; Borràs, Eva (Universitat Pompeu Fabra. Centre de Regulació Genòmica (CRG-UPF)) ; Sabidó, Eduard (Universitat Pompeu Fabra. Centre de Regulació Genòmica (CRG-UPF)) ; Forés Vineta, Joaquim (Hospital Clínic i Provincial de Barcelona) ; Aloy, Patrick (Institució Catalana de Recerca i Estudis Avançats)
Neurodegenerative processes are preceded by neuronal dysfunction and synaptic disconnection. Disconnection between spinal motoneuron (MN) soma and synaptic target leads either to a retrograde degenerative process or to a regenerative reaction, depending injury proximity among other factors. [...]
2015 - 10.1038/srep09185
Scientific reports, Vol. 5 (2015) , art. 9185  
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13.
11 p, 4.2 MB Neuregulin 1 Reduces Motoneuron Cell Death and Promotes Neurite Growth in an in Vitro Model of Motoneuron Degeneration / Mòdol Caballero, Guillem (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Santos, Daniel (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències)
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disorder with no effective treatment currently available. Although the mechanisms of motoneuron (MN) death are still unclear, glutamate excitotoxicity and neuroinflammatory reaction are two main features in the neurodegenerative process of ALS. [...]
2018 - 10.3389/fncel.2017.00431
Frontiers in cellular neuroscience, Vol. 11 (january 2018)  
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14.
10 p, 3.4 MB Neuroprotective Effect of Non-viral Gene Therapy Treatment Based on Tetanus Toxin C-fragment in a Severe Mouse Model of Spinal Muscular Atrophy / Oliván, Sara (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Calvo, Ana Cristina (Universidad de Zaragoza. Facultad de Veterinaria. Laboratorio de Genética Bioquímica) ; Rando, Amaya (Universidad de Zaragoza. Facultad de Veterinaria. Laboratorio de Genética Bioquímica) ; Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Manzano Martínez, Raquel (University of Oxford. Department of Physiology, Anatomy and Genetics) ; Zaragoza, Pilar (Universidad de Zaragoza. Instituto Agroalimentario de Aragón) ; Tizzano, Eduardo F. (Hospital Universitari Vall d'Hebron) ; Aguilera, José (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Osta, Rosario (Centro de Investigación y Tecnología Agroalimentaria de Aragón) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Spinal muscular atrophy (SMA) is a hereditary childhood disease that causes paralysis and progressive degeneration of skeletal muscles and spinal motor neurons. SMA is associated with reduced levels of full-length Survival of Motor Neuron (SMN) protein, due to mutations in the Survival of Motor Neuron 1 gene. [...]
2016 - 10.3389/fnmol.2016.00076
Frontiers in molecular neuroscience, Vol. 9 (August 2016) , art. 76  
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15.
14 p, 11.1 MB Early presymptomatic cholinergic dysfunction in a murine model of amyotrophic lateral sclerosis / Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Manzano Martínez, Raquel (Universidad de Zaragoza) ; Mancuso, Renzo (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Osta, Rosario (Universidad de Zaragoza) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Sporadic and familiar amyotrophic lateral sclerosis (ALS) cases presented lower cholinergic activity than in healthy individuals in their still preserved spinal motoneurons (MNs) suggesting that cholinergic reduction might occur before MN death. [...]
2013 - 10.1002/brb3.104
Brain and behavior, Vol. 3, Núm. 2 (February 2013) , p. 145-158  
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16.
17 p, 5.8 MB Novel Neuroprotective Multicomponent Therapy for Amyotrophic Lateral Sclerosis Designed by Networked Systems / Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Mulet, Roger (Anaxomics Biotech) ; Pujol, Albert (Institut de Recerca Biomèdica de Lleida) ; Mas, José Manuel (Anaxomics Biotech) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Aloy, Patrick (Institut de Recerca Biomèdica de Lleida) ; Coma, Mireia (Anaxomics Biotech) ; Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències)
Amyotrophic Lateral Sclerosis is a fatal, progressive neurodegenerative disease characterized by loss of motor neuron function for which there is no effective treatment. One of the main difficulties in developing new therapies lies on the multiple events that contribute to motor neuron death in amyotrophic lateral sclerosis. [...]
2016 - 10.1371/journal.pone.0147626
PloS one, Vol. 11, Num. 1 (January 2016) , p. 1-17  
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