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22 p, 1.4 MB |
Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers
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Jansen, Iris (Vrije Universiteit Amsterdam) ;
van der Lee, Sven J (Vrije Universiteit Amsterdam) ;
Gomez-Fonseca, Duber (Washington University School of Medicine) ;
De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Dalmasso, Maria Carolina (Neurosciences and Complex Systems Unit (ENyS). CONICET. Hospital El Cruce. National University A. Jauretche (UNAJ)) ;
Grenier-Boley, Benjamin (Université de Lille) ;
Zettergren, Anna (University of Gothenburg) ;
Mishra, Aniket (Université de Bordeaux) ;
Ali, Muhammad (Washington University School of Medicine) ;
Andrade, Victor (University Hospital Bonn. Medical Faculty) ;
Bellenguez, Céline (Université de Lille) ;
Kleineidam, Luca (German Center for Neurodegenerative Diseases (DZNE)) ;
Küçükali, Fahri (University of Antwerp. Department of Biomedical Sciences) ;
Sung, Ju Sung (Washington University School of Medicine) ;
Tesí, Niccolo (Vrije Universiteit Amsterdam) ;
Vromen, Ellen (Amsterdam Neuroscience. Neurodegeneration) ;
Wightman, Douglas P (Vrije Universiteit Amsterdam) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Alvarez, Ignacio (Fundació per a la Recerca Biomèdica i Social Mútua de Terrassa) ;
Amouyel, Philippe (Université de Lille) ;
Athanasiu, Lavinia (NORMENT Centre. Institute of Clinical Medicine. University of Oslo and Division of Mental Health) ;
Bahrami, Shahram (NORMENT Centre. Institute of Clinical Medicine. University of Oslo and Division of Mental Health) ;
Bailly, Henri (Université Paris Cité) ;
Belbin, Olivia (Institut d'Investigació Biomèdica Sant Pau) ;
Bergh, Sverre (Vestfold Hospital Trust) ;
Bertram, Lars (University of Lübeck) ;
Biessels, Geert Jan (UMC Utrecht Brain Center) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Blesa, Rafael (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Boland, Anne (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ;
Buerger, K. (Institute for Stroke and Dementia Research (ISD). University Hospital. LMU Munich) ;
Carracedo, Ángel (Fundación Pública Galega de Medicina Xenómica-CIBERER-IDIS) ;
Cervera Carles, Laura (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Chene, Geneviève (Department of Neurology. CHU de Bordeaux) ;
Claassen, Jurgen (Donders Center for Medical Neuroscience) ;
Debette, Stephanie (University School of Medicine) ;
Deleuze, Jean‑Francois (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ;
De Deyn, Peter Paul (University Medical Center Groningen. Department of Neurology and Alzheimer Center Groningen.) ;
Diehl-Schmid, Janine (kbo-Inn-Salzach-Hospital) ;
Djurovic, Srdjan (University of Bergen. Department of Clinical Science. NORMENT Centre.) ;
Dols Icardo, Oriol (Institut d'Investigació Biomèdica Sant Pau) ;
Dufouil, Carole (Pôle de Santé Publique) ;
Duron, Emmanuelle (Univerisité Paris-Saclay) ;
Düzel, Emrah (Otto-von-Guericke University Magdeburg. Institute of Cognitive Neurology and Dementia Research) ;
Fladby, Tormod (Akershus University Hospital. Department of Neurology.) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Frölich, Lutz (Medical Faculty Mannheim. Department of Geriatric Psychiatry. Central Institute of Mental Health.) ;
García-González, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Garcia-Martinez, María (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Giegling, Ina (Medical University of Vienna) ;
Goldhardt, Oliver (Technical University of Munich) ;
Gobom, Johan (Sahlgrenska University Hospital (Suècia)) ;
Grimmer, Timo (Technical University of Munich) ;
Haapasalo, Annakaisa (University of Eastern Finland A.I. Virtanen Institute for Molecular Sciences) ;
Hampel, Harald (Neurology Business Group. Eisai Inc) ;
Hanon, Olivier (Service gériatrie. Centre Mémoire de Ressources et Recherches Ile de France-Broca. AP-HP. Hôpital Broca) ;
Hausner, Lucrezia (Central Institute of Mental Health. Department of Geriatric Psychiatry) ;
Heilmann-Heimbach, Stefanie (Institute of Human Genetics. University of Bonn. School of Medicine and University Hospital Bonn) ;
Helisalmi, Seppo (University of Eastern Finland. Institute of Clinical Medicine) ;
Heneka, Michael (German Center for Neurodegenerative Diseases (DZNE)) ;
Hernández, Isabel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Herukka, Sanna‑Kaisa (University of Eastern Finland. Department of Neurology. Institute of Clinical Medicine) ;
Holstege, Henne (Vrije Universiteit Amsterdam. Section Genomics of Neurodegenerative Diseases and Aging) ;
Jarholm, Jonas (Akershus University Hospital. Department of Neurology.) ;
Kern, Silke (Sahlgrenska University Hospital. Psychiatry. Cognition and Old Age Psychiatry Clinic) ;
Knapskog, Anne‑Brita (Oslo University Hospital. Department of Geriatric Medicine) ;
Koivisto, A.M. (Department of Neurology. Helsinki University Hospital) ;
Kornhuber, Johannes (Friedrich-Alexander Universität Erlangen-Nürnberg) ;
Kuulasmaa, Teemu (University of Eastern Finland) ;
Lage, Carmen (University of California) ;
Laske, Christoph (University of Tübingen. Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy.) ;
Leinonen, Ville (Kuopio University Hospita. Department of Neurosurgery.) ;
Lewczuk, Piotr (Medical University of Białystok. Department of Neurodegeneration Diagnostics.) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
López de Munain, Adolfo (University of The Basque Country) ;
López-Garcia, Sara (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Maier, Wolfgang (University Hospital Bonn. Department of Neurodegenerative Diseases and Geriatric Psychiatry) ;
Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Mol, Merel O. (Erasmus Medical Centre. Department of Neurology) ;
Montrreal, Laura (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Moreno, Fermin (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Moreno-Grau, Sonia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Nicolas, Gael (Normandie Univ. UNIROUEN. Department of Genetics and CNR-MAJ) ;
Nöthen, Markus M. (Institute of Human Genetics. University of Bonn. School of Medicine and University Hospital Bonn) ;
Orellana, Adelina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Pålhaugen, Lene (Akershus University Hospital. Department of Neurology) ;
Papma, Janne M. (Erasmus MC University Medical Center. Department of Neurology and Alzheimer Center Erasmus MC) ;
Pasquier, Florence (Université Lille) ;
Perneczky, Robert (Imperial College London. Ageing Epidemiology Research Unit) ;
Peters, Oliver (German Center for Neurodegenerative Diseases (DZNE)) ;
Pijnenburg, Yolande A.L. (Amsterdam Neuroscience. Neurodegeneration) ;
Popp, Julius (University Hospital of Lausanne. Department of Psychiatry) ;
Posthuma, Danielle (Vrije Universiteit Amsterdam) ;
Pozueta, Ana (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Priller, Josef (Technical University Munich. Department of Psychiatry and Psychotherapy) ;
Puerta, Raquel (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Quintela, Inés (Grupo de Medicina Xenómica. Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII). Universidade de Santiago de Compostela) ;
Ramakers, Inez (Maastricht University. Department of Psychiatry and Neuropsychologie) ;
Rodríguez-Rodríguez, Eloy (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Rujescu, Dan (Medical University of Vienna. Department of Psychiatry and Psychotherapy) ;
Saltvedt, Ingvild (University Hospital of Trondheim. Department of Geriatrics) ;
Sánchez-Juan, Pascual (Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII) ;
Scheltens, Philip (Amsterdam Neuroscience. Neurodegeneration) ;
Scherbaum, Norbert (University of Duisburg-Essen) ;
Schmid, Matthias (University Hospital of Bonn. Institute of Medical Biometry) ;
Schneider, Anja (German Center for Neurodegenerative Diseases (DZNE)) ;
Selbæk, Geir (Oslo University Hospital.Department of Geriatric Medicine) ;
Selnes, Per (Akershus University Hospital. Department of Neurology) ;
Shadrin, Alexey (University of Oslo and Division of Mental Health. Institute of Clinical Medicine) ;
Skoog, Ingmar (Sahlgrenska University Hospital (Suècia)) ;
Soininen, Hilkka (University of Eastern Finland. Institute of Clinical Medicine.) ;
Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Teipel, Stefan (Rostock University Medical Center. Department of Psychosomatic Medicine) ;
Tijms, Betty M (Amsterdam Neuroscience. Neurodegeneration) ;
Tsolaki, Magda (Aristotle University of Thessaloniki) ;
Van Broeckhoven, Christine (Neurodegenerative Brain Diseases Group. VIB Center for Molecular Neurology. VIB) ;
Van Dongen, Jasper (University of Antwerp. Department of Biomedical Sciences) ;
van Swieten, John C. (Erasmus MC University Medical Center) ;
Vandenberghe, Rik (Leuven Brain Institute. Department of Neurosciences.) ;
Vidal, Jean‑Sébastien (Université Paris Cité) ;
Visser, Pieter J. (Division of Neurogeriatrics Karolinska Institutet. Department of Neurobiology) ;
Vogelgsang, Jonathan (Harvard Medical School. Department of Psychiatry) ;
Waern, Margda (Sahlgrenska University Hospital (Suècia)) ;
Wagner, Michael (German Center for Neurodegenerative Diseases (DZNE)) ;
Wiltfang, Jens W (Medical Science Department. iBiMED) ;
Wittens, Mandy M.J. (Vrije Universiteit Brussel) ;
Zetterberg, Henrik (Hong Kong Center for Neurodegenerative Diseases) ;
Zulaica, Miren (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
van Duijn, Cornelia M. (Nuffield Department of Population Health. Oxford University) ;
Bjerke, Maria (Universitair Ziekenhuis Brussel) ;
Engelborghs, Sebastiaan (Universitair Ziekenhuis Brussel. Department of Neurology) ;
Jessen, Frank (University of Cologne) ;
Teunissen, Charlotte E. (Vrije Universiteit Amsterdam) ;
Pastor, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hiltunen, Mikko (University of Eastern Finland. Institute of Biomedicine) ;
Ingelsson, Martin (University of Toronto. Department of Medicine) ;
Andreassen, Ole A (Oslo University Hospital (Oslo, Noruega)) ;
Clarimón, Jordi (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sleegers, Kristel (University of Antwerp. Department of Biomedical Sciences) ;
Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ramirez, Alfredo (Department of Psychiatry. Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ;
Cruchaga, Carlos (Washington University School of Medicine. Hope Center for Neurological Disorders) ;
Lambert, Jean-Charles (Institut Pasteur de Lille) ;
van der Flier, Wiesje M (Amsterdam Neuroscience. Neurodegeneration) ;
Universitat Autònoma de Barcelona
Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly than clinical diagnosis. Initiated by the European Alzheimer & Dementia Biobank (EADB), the largest collaborative effort on genetics underlying CSF biomarkers was established, including 31 cohorts with a total of 13,116 individuals (discovery n = 8074; replication n = 5042 individuals). [...]
2022 -  10.1007/s00401-022-02454-z
Acta Neuropathologica, Vol. 144 Núm. 5 (november 2022) , p. 821-842
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12.
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14 p, 3.0 MB |
Genome-Wide Association Study of Alzheimer's Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery Dataset
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Homann, Jan (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ;
Osburg, Tim (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ;
Ohlei, Olena (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ;
Dobricic, Valerija (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ;
Deecke, Laura (Lübeck Interdisciplinary Platform for Genome Analytics. University of Lübeck) ;
Bos, Isabelle (Vrije Universiteit Amsterdam) ;
Vandenberghe, Rik (Neurology Service. University Hospital Leuven) ;
Gabel, Silvy (Laboratory for Cognitive Neurology. Department of Neurosciences. KU Leuven) ;
Scheltens, Philip (Vrije Universiteit Amsterdam) ;
Teunissen, Charlotte E. (Vrije Universiteit Amsterdam) ;
Engelborghs, Sebastiaan (Vrije Universiteit Amsterdam) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Blin, Olivier (Institut Neurosciences Timone. AIX Marseille University) ;
Richardson, Jill C. (Neurosciences Therapeutic Area. GlaxoSmithKline RD) ;
Bordet, Régis (Lille Neuroscience and Cognition. University of Lille. Inserm. CHU Lille) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, Julius (Old Age Psychiatry. Department of Psychiatry. University Hospital of Lausanne) ;
Clark, Christopher (Department of Geriatric Psychiatry. University Hospital of Psychiatry Zurich) ;
Peyratout, Gwendoline (Old Age Psychiatry. Department of Psychiatry. University Hospital of Lausanne) ;
Martinez-Lage, Pablo (Department of Neurology. Center for Research and Advanced Therapies. CITA-Alzheimer Foundation) ;
Tainta, Mikel (Department of Neurology. Center for Research and Advanced Therapies. CITA-Alzheimer Foundation) ;
Dobson, Richard J.B. (NIHR Biomedical Research Centre at University College London Hospitals NHS Foundation Trust) ;
Legido-Quigley, Cristina (King's College London. Institute of Pharmaceutical Sciences) ;
Sleegers, Kristel (Center for Molecular Neurology) ;
Van Broeckhoven, Christine (University of Antwerp) ;
Wittig, Michael (Christian-Albrechts-University of Kiel. Institute of Clinical Molecular Biology) ;
Franke, Andre (Christian-Albrechts-University of Kiel. Institute of Clinical Molecular Biology) ;
Lill, Christina M. (Ageing Epidemiology Research Unit. School of Public Health. Imperial College London) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (University College London. UK Dementia Research Institute) ;
Lovestone, Simon (University of Oxford. Department of Psychiatry) ;
Streffer, Johannes ;
ten Kate, Mara (Amsterdam UMC. University Medical Center) ;
Vos, Stephanie J.B. (Maastricht University) ;
Barkhof, Frederik (University College London) ;
Visser, Pieter Jeller (Karolinska Institutet. Department of Neurobiology) ;
Bertram, Lars (University of Oslo)
Alzheimer's disease (AD) is the most frequent neurodegenerative disease with an increasing prevalence in industrialized, aging populations. AD susceptibility has an established genetic basis which has been the focus of a large number of genome-wide association studies (GWAS) published over the last decade. [...]
2022 - 10.3389/fnagi.2022.840651
Frontiers in aging neuroscience, Vol. 14 (March 2022) , p. 840651
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19 p, 1.3 MB |
State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease
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Hampel, Harald (Eisai Inc. Neurology Business Group) ;
Shaw, Leslie M. (Perelman School of Medicine. Department of Pathology and Laboratory Medicine. University of Pennsylvania) ;
Aisen, Paul (USC Alzheimer's Therapeutic Research Institute) ;
Chen, Christopher (Memory Aging and Cognition Centre. Departments of Pharmacology and Psychological Medicine. Yong Loo Lin School of Medicine. National University of Singapore) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Iwatsubo, Takeshi (Department of Neuropathology. Graduate School of Medicine. The University of Tokyo) ;
Iwata, Atsushi (Tokyo Metropolitan Geriatric Hospital) ;
Yamada, Masahito (Department of Neurology and Neurobiology of Aging. Kanazawa University Graduate School of Medical Science) ;
Ikeuchi, Takeshi (Department of Molecular Genetics. Brain Research Institute. Niigata University) ;
Jia, Jianping (Innovation Center for Neurological Disorders. Department of Neurology. Xuan Wu Hospital. Capital Medical University) ;
Wang, Huali (Dementia Care and Research Center. Peking University Institute of Mental Health (Sixth Hospital). Beijing Dementia Key Lab. National Clinical Research Center for Mental Disorders) ;
Teunissen, Charlotte E. (Amsterdam University Medical Centers (AUMC)) ;
Peskind, Elaine (VA Northwest Mental Illness Research. Education and Clinical Center. VA Puget Sound Health Care System. Department of Psychiatry and Behavioral Sciences. University of Washington School of Medicine) ;
Blennow, Kaj (Clinical Neurochemistry Laboratory. Sahlgrenska University Hospital) ;
Cummings, Jeffrey (Chambers-Grundy Center for Transformative Neuroscience. Department of Brain Health. School of Integrated Health Sciences. University of Nevada Las Vegas (UNLV)) ;
Vergallo, Andrea (Eisai Inc. Neurology Business Group) ;
Universitat Autònoma de Barcelona
Recent advances in developing disease-modifying therapies (DMT) for Alzheimer's disease (AD), and the recognition that AD pathophysiology emerges decades before clinical symptoms, necessitate a paradigm shift of health-care systems toward biomarker-guided early detection, diagnosis, and therapeutic decision-making. [...]
2022 - 10.1002/alz.12372
Alzheimer's & Dementia, Vol. 18 Núm. 1 (january 2022) , p. 159-177
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14.
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9 p, 1.5 MB |
The use of lumbar puncture and safety recommendations in Alzheimer's disease : a plain language summary
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Hampel, Harald (Eisai Inc. Neurology Business Group) ;
Elhage, Aya (Eisai Inc. Neurology Business Group) ;
Shaw, Leslie M. (Perelman School of Medicine. Department of Pathology & Laboratory Medicine. University of Pennsylvania) ;
Aisen, Paul (Usc Alzheimer's Therapeutic Research Institute) ;
Chen, Christopher (Memory Aging & Cognition Centre. Departments of Pharmacology & Psychological Medicine. Yong Loo Lin School of Medicine. National University of Singapore) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Iwatsubo, Takeshi (Department of Neuropathology. Graduate School of Medicine. The University of Tokyo) ;
Iwata, Atsushi (Tokyo Metropolitan Geriatric Hospital) ;
Yamada, Masahito (Department of Neurology & Neurological Science. Tokyo Medical & Dental University) ;
Ikeuchi, Takeshi (Department of Molecular Genetics. Brain Research Institute. Niigata University) ;
Jia, Jianping (Innovation Center for Neurological Disorders. Department of Neurology. Xuan Wu Hospital. Capital Medical University) ;
Wang, Huali (Dementia Care & Research Center. Peking University Institute of Mental Health (Sixth Hospital). Beijing Dementia Key Lab. National Clinical Research Center for Mental Disorders) ;
Teunissen, Charlotte E. (Amsterdam University Medical Centers (AUMC)) ;
Peskind, Elaine (Va Northwest Mental Illness Research. Education & Clinical Center. Va Puget Sound Health Care System. Department of Psychiatry & Behavioral Sciences. University of Washington School of Medicine) ;
Blennow, Kaj (Clinical Neurochemistry Laboratory. Sahlgrenska University Hospital) ;
Cummings, Jeffrey (Chambers-Grundy Center for Transformative Neuroscience. Department of Brain Health. School of Integrated Health Sciences. University of Nevada Las Vegas (UNLV)) ;
Vergallo, Andrea (Eisai Inc. Neurology Business Group) ;
Universitat Autònoma de Barcelona
What is this summary about? This is a plain language summary of an article published in Alzheimer's & Dementia. It looks at a type of test called a lumbar puncture (also known as spinal tap) used in people suspected of having Alzheimer's disease or some other form of dementia. [...]
2022 - 10.2217/nmt-2022-0012
Neurodegenerative Disease Management, Vol. 12 Núm. 5 (january 2022) , p. 221-229
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12 p, 312.7 KB |
Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease : An international overview
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Delaby, Constance (Institut d'Investigació Biomèdica Sant Pau) ;
Teunissen, Charlotte E. (Vrije Universiteit Amsterdam) ;
Blennow, Kaj (The Sahlgrenska Academy at the University of Gothenburg) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Arisi, Ivan (European Brain Research Institute (EBRI) "Rita Levi-Montalcini") ;
Amar, Elodie Bouaziz (GHU APHP Nord Lariboisière Fernand-Widal Hospital) ;
Beaume, Anne (CHU Poitiers) ;
Bedel, Aurelie (CHU Bordeaux) ;
Bellomo, Giovanni (University of Perugia) ;
Bigot-Corbel, Edith (CHU de Nantes) ;
Bjerke, Maria (University of Antwerp) ;
Blanc-Quintin, Marie-Céline (APHP Centre-Université de Paris, Cochin Hospital) ;
Boada, Mercè (Instituto de Salud Carlos III) ;
Bousiges, Olivier (Hôpitaux Universitaires de Strasbourg) ;
Chapman, Miles D (National Hospital for Neurology and Neurosurgery, UCL Queen Square) ;
DeMarco, Mari L. (University of British Columbia) ;
D'Onofrio, Mara (European Brain Research Institute (EBRI) "Rita Levi-Montalcini") ;
Dumurgier, Julien (GHU APHP Nord Lariboisière Fernand-Widal Hospital) ;
Dufour-Rainfray, Diane (CHU Tours) ;
Engelborghs, Sebastiaan (Center for Neurosciences and Department of Neurology) ;
Esselmann, Hermann (University Medical Center Goettingen (UMG) ;
Fogli, Anne (CHU Clermont-Ferrand) ;
Gabelle, Audrey (INSERM) ;
Galloni, Elisabetta (Dipartimento di Neuroscienze Divisione di Neurologia) ;
Gondolf, Clémentine (CHU Cote de Nacre Caen) ;
Grandhomme, Frédérique (CHU Cote de Nacre Caen) ;
Grau-Rivera, Oriol (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Hart, Melanie (National Hospital for Neurology and Neurosurgery, UCL Queen Square) ;
Ikeuchi, Takeshi (Niigata University) ;
Jeromin, Andreas (Cohen Veterans Bioscience) ;
Kasuga, Kensaku (Niigata University) ;
Keshavan, Ashvini (UCL Institute of Neurology (Regne Unit)) ;
Khalil, Michael (Medical University of Graz) ;
Körtvelyessy, Peter (German Center for Neurodegenerative Diseases, Magdeburg, Germany and Charité-Universitäts medizin Berlin) ;
Kulczynska-Przybik, Agnieszka (Medical University of Bialystok) ;
Laplanche, Jean-Louis (GHU APHP Nord Lariboisière Fernand-Widal Hospital) ;
Lewczuk, Piotr (Universitätsklinikum Erlangen and Friedrich-Alexander Universität Erlangen-Nürnberg) ;
Li, Qiao-Xin (Florey Institute and The University of Melbourne) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Malaplate, Catherine (Biologie Moléculaire et Nutrition/ Université de Lorraine) ;
Marquié, Marta (Instituto de Salud Carlos III) ;
Masters, Colin L. (Florey Institute and The University of Melbourne) ;
Mroczko, Barbara (Medical University of Bialystok) ;
Nogueira, Léonor (CHU PURPAN) ;
Orellana, Adelina (Instituto de Salud Carlos III) ;
Otto, Markus (University of Ulm) ;
Oudart, Jean-Baptiste (Université de Reims Champagne-Ardenne) ;
Paquet, Claire (GHU APHP Nord Lariboisière Fernand-Widal Hospital) ;
Paoletti, Federico Paolini (University of Perugia) ;
Parnetti, Lucilla (University of Perugia) ;
Perret-Liaudet, Armand (Lyon University Hospital) ;
Peoc'h, Katell (Université de Paris GHU APHP Nord Beaujon Hospital) ;
Poesen, Koen (Leuven Brain Institute) ;
Puig-Pijoan, Albert (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Quadrio, Isabelle (Lyon University Hospital) ;
Quillard-Muraine, Muriel (Normandie Univ) ;
Rucheton, Benoit (AP-HP Sorbonne University) ;
Schraen, Susanna (Université de Lille) ;
Schott, Jonathan M. (UCL Institute of Neurology (Regne Unit)) ;
Shaw, Leslie M. (University of Pennsylvania) ;
Suárez-Calvet, Marc (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Tsolaki, Magda (Aristotle University of Thessaloniki) ;
Tumani, Hayrettin (University of Ulm) ;
Udeh-Momoh, Chinedu T (Imperial College London) ;
Vaudran, Lucie (Univ. Lille) ;
Verbeek, Marcel M (Radboud University Medical Center) ;
Verde, Federico ("Dino Ferrari" Center, Università degli Studi di Milano) ;
Vermunt, Lisa (Vrije Universiteit Amsterdam) ;
Vogelgsang, Jonathan (Harvard Medical School) ;
Wiltfang, Jens (University of Aveiro) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Lehmann, Sylvain (Université de Montpellier) ;
Universitat Autònoma de Barcelona
The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests. [...]
2021 - 10.1002/alz.12545
Alzheimer's & Dementia, Vol. 18 (december 2021) , p. 1868-1879
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15 p, 1.6 MB |
Contactin-1 links autoimmune neuropathy and membranous glomerulonephritis
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Fehmi, Janev (University of Oxford) ;
Davies, Alexander J. (University of Oxford) ;
Antonelou, Marilina (University College London) ;
Keddie, Stephen (National Hospital of Neurology and Neurosurgery (Regne Unit)) ;
Pikkupeura, Sonja (University of Oxford) ;
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Delmont, Emilien (Hospital La Timone (França)) ;
Cortese, Andrea (University of Pavia) ;
Franciotta, Diego (Mondino Foundation) ;
Persson, Staffan (Lund University) ;
Barratt, Jonathan (University of Leicester) ;
Pepper, Ruth (University College London) ;
Farinha, Filipa (University College London) ;
Rahman, Anisur (University College London) ;
Canetti, Diana (University College London) ;
Gilbertson, Janet A. (University College London) ;
Rendell, Nigel B. (University College London) ;
Radunovic, Aleksandar (Royal London Hospital) ;
Minton, Thomas (University of Bristol) ;
Fuller, Geraint (Gloucestershire Royal Hospital) ;
Murphy, Sinead M. (Tallaght University Hospital & Academic Unit of Neurology (Irlanda)) ;
Carr, Aisling S. (UCL Institute of Neurology (Regne Unit)) ;
Reilly, Mary R. (UCL Institute of Neurology (Regne Unit)) ;
Eftimov, Filip (Amsterdam UMC) ;
Wieske, Luuk (Amsterdam UMC) ;
Teunissen, Charlotte E. (Amsterdam UMC) ;
Roberts, Ian S. D. (John Radcliffe Hospital (Regne Unit)) ;
Ashman, Neil (The Royal London Hospital (Regne Unit)) ;
Salama, Alan D. (University College London Department of Renal Medicine (Regne Unit)) ;
Rinaldi, Simon (University of Oxford) ;
Universitat Autònoma de Barcelona
Membranous glomerulonephritis (MGN) is a common cause of nephrotic syndrome in adults, mediated by glomerular antibody deposition to an increasing number of newly recognised antigens. Previous case reports have suggested an association between patients with anti-contactin-1 (CNTN1)-mediated neuropathies and MGN. [...]
2023 - 10.1371/journal.pone.0281156
PloS one, Vol. 18 (march 2023)
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17.
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13 p, 1.9 MB |
Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis : A systematic review and meta-analysis
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Hegen, Harald (Medical University of Innsbruck) ;
Walde, Janette (University of Innsbruck) ;
Berek, Klaus (University of Innsbruck) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Gnanapavan, Sharmilee (Queen Mary University of London) ;
Kaplan, Batia (Sheba Medical Center (Israel)) ;
Khalil, Michael (Medical University of Graz) ;
Saadeh, Ruba (Clínica Mayo) ;
Teunissen, Charlotte E (Vrije Universiteit) ;
Tumani, Hayrettin (University of Ulm) ;
Villar, Luisa M (Hospital Universitario Ramón y Cajal (Madrid)) ;
Willrich, Maria Alice V (Clínica Mayo) ;
Zetterberg, Henrik (Sahlgrenska University Hospital (Suècia)) ;
Deisenhammer, Florian ;
Universitat Autònoma de Barcelona
Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which can be detected by oligoclonal IgG bands (OCB) or by κ-free light chains (κ-FLC) in cerebrospinal fluid. To perform a systematic review and meta-analysis to evaluate whether κ-FLC index has similar diagnostic value to identify patients with clinically isolated syndrome (CIS) or MS compared to OCB, and to determine κ-FLC index cut-off. [...]
2022 - 10.1177/13524585221134213
Multiple sclerosis, Vol. 29 (december 2022) , p. 169-181
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18.
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14 p, 1.1 MB |
Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis : A consensus statement
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Hegen, Harald (Medical University of Innsbruck) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Gnanapavan, Sharmilee (Queen Mary University of London) ;
Kaplan, Batia (Sheba Medical Center) ;
Khalil, Michael (Medical University of Graz) ;
Saadeh, Ruba (Mayo Clinic (Rochester)) ;
Teunissen, Charlotte E (Amsterdam UMC) ;
Tumani, Hayrettin (University of Ulm) ;
Villar, Luisa Maria (Hospital Universitario Ramón y Cajal (Madrid)) ;
Willrich, Maria Alice V (Mayo Clinic) ;
Zetterberg, Henrik (Sahlgrenska University Hospital (Suècia)) ;
Deisenhammer, Florian (Medical University of Innsbruck) ;
Universitat Autònoma de Barcelona
Cerebrospinal fluid (CSF) analysis is of utmost importance for diagnosis and differential diagnosis of patients with suspected multiple sclerosis (MS). Evidence of intrathecal immunoglobulin G (IgG) synthesis proves the inflammatory nature of the disease, increases diagnostic certainty and substitutes for dissemination in time according to current diagnostic criteria. [...]
2022 - 10.1177/13524585221134217
Multiple sclerosis, Vol. 29 (december 2022) , p. 182-195
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19.
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13 p, 1.8 MB |
Replication study of plasma proteins relating to Alzheimer's pathology
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Shi, Liu (University of Oxford. Department of Psychiatry) ;
Winchester, Laura M. (University of Oxford. Department of Psychiatry) ;
Westwood, Sarah (University of Oxford. Department of Psychiatry) ;
Baird, Alison L (University of Oxford. Department of Psychiatry) ;
Anand, Sneha N (University of Oxford. Department of Psychiatry) ;
Buckley, Noel J. (University of Oxford. Department of Psychiatry) ;
Hye, Abdul (Maurice Wohl Clinical Neuroscience. Institute of Psychiatry. Psychology and Neuroscience. Kings College London) ;
Ashton, Nicholas J. (University of Gothenburg) ;
Bos, Isabelle (Alzheimer Center. VU University Medical Center) ;
Vos, Stephanie J.B. (Maastricht University. School for Mental Health and Neuroscience) ;
Kate, Mara Ten (Amsterdam UMC. University Medical Center) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Teunissen, Charlotte E. (Amsterdam University Medical Centers (AUMC)) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Gabel, Silvy (KU Leuven. Laboratory for Cognitive Neurology) ;
Meersmans, Karen (KU Leuven. Laboratory for Cognitive Neurology) ;
Engelborghs, Sebastiaan (Department of Neurology. UZ Brussel and Center for Neurociences (C4N). Vrije Universiteit Brussel) ;
De Roeck, Ellen E (Department of Neurology and Memory Clinic. Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken) ;
Sleegers, Kristel (University of Antwerp. Institute Born-Bunge) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Blin, Olivier (AIX marseille university. INS. Ap-hm) ;
Richardson, Jill C. (Neurosciences Therapeutic Area. GlaxoSmithKline R&D) ;
Bordet, Régis (Inserm. University of Lille. CHU Lille) ;
Molinuevo, José Luis (Barcelonaβeta Brain Research Center (BBRC)) ;
Rami Gonzalez, Lorena (Barcelonaβeta Brain Research Center (BBRC)) ;
Wallin, Anders (Institute of Neuroscience and Physiology. Sahlgrenska Academy at University of Gothenburg) ;
Kettunen, Petronella (Institute of Neuroscience and Physiology. Sahlgrenska Academy at University of Gothenburg) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University. School for Mental Health and Neuroscience) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, Julius (Geriatric Psychiatry. Department of Mental Health and Psychiatry. Geneva University Hospitals) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Martinez-Lage, Pablo (CITA-Alzheimer Foundation) ;
Tainta, Mikel (CITA-Alzheimer Foundation) ;
Johannsen, Peter (Danish Dementia Research Centre. Rigshospitalet. Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska Institutet Center for Alzheimer Research. Division of Clinical Geriatrics. School of Medical Sciences Örebro University and Department of Neurobiology. Caring Sciences and Society (NVS)) ;
Frölich, Lutz (Department of Geriatric Psychiatry. Zentralinstitut für Seelische Gesundheit. University of Heidelberg) ;
Dobricic, Valerija (Lübeck Interdisciplinary Platform for Genome Analytics. Institutes of Neurogenetics and Cardiogenetics. University of Lübeck) ;
Legido-Quigley, Cristina (The Systems Medicine Group. Steno Diabetes Center) ;
Barkhof, Frederik (UCL Institutes of Neurology and Healthcare Engineering) ;
Andreasson, Ulf (Clinical Sahlgrenska University Hospital) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Streffer, Johannes (UCB. Braine-l'Alleud. Belgium. formerly Janssen R&D. LLC Beerse) ;
Lill, Christina M. (Ageing Epidemiology Research Unit. School of Public Health. Imperial College) ;
Bertram, Lars (Department of Psychology. University of Oslo) ;
Visser, Pieter Jelle (Alzheimer Center. VU University Medical Center) ;
Kolb, Hartmuth C. (Janssen R&D) ;
Narayan, Vaibhav A. (Janssen R&D) ;
Lovestone, Simon (Janssen R&D) ;
Nevado-Holgado, Alejo (Department of Psychiatry. University of Oxford)
Introduction: This study sought to discover and replicate plasma proteomic biomarkers relating to Alzheimer's disease (AD) including both the "ATN" (amyloid/tau/neurodegeneration) diagnostic framework and clinical diagnosis. [...]
2021 - 10.1002/alz.12322
Alzheimer's & Dementia, Vol. 17 Núm. 9 (september 2021) , p. 1452-1464
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20.
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13 p, 2.5 MB |
TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels
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Hong, Shengjun (Lübeck Interdisciplinary Platform for Genome Analytics (LIGA). University of Lübeck) ;
Dobricic, Valerija (Lübeck Interdisciplinary Platform for Genome Analytics (LIGA). University of Lübeck) ;
Ohlei, Olena (Lübeck Interdisciplinary Platform for Genome Analytics (LIGA). University of Lübeck) ;
Bos, Isabelle (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Vrije Universiteit Amsterdam) ;
Vos, Stephanie J.B. (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Vrije Universiteit Amsterdam) ;
Prokopenko, Dimitry (Massachusetts General Hospital (Boston)) ;
Tijms, Betty M. (Vrije Universiteit Amsterdam) ;
Andreasson, Ulf (Sahlgrenska University Hospital (Suècia)) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Gabel, Silvy (KU Leuven. Department of Neurosciences) ;
Scheltens, Philip (Vrije Universiteit Amsterdam) ;
Teunissen, Charlotte E. (Amsterdam University Medical Centers (AUMC)) ;
Engelborghs, Sebastiaan (Vrije Universiteit Brussel) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Blin, Olivier (AIX Marseille University. INS. Ap-hm) ;
Richardson, Jill C. (Neurosciences Therapeutic Area. GlaxoSmithKline R&D) ;
Bordet, Régis (Inserm. CHU Lille. University of Lille) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, Julius (Lausanne University Hospital) ;
Clark, Christopher (University Hospital of Psychiatry Zurich) ;
Peyratout, Gwendoline (University Hospital of Lausanne. Department of Psychiatry) ;
Martinez-Lage, Pablo (Department of Neurology. Center for Research and Advanced Therapies. CITA-Alzheimer Foundation) ;
Tainta, Mikel (Department of Neurology. Center for Research and Advanced Therapies. CITA-Alzheimer Foundation) ;
Dobson, Richard J.B. (University College London. Hospitals Biomedical Research Centre) ;
Legido-Quigley, Cristina (King's College London) ;
Sleegers, Kristel (University of Antwerp. Institute Born-Bunge) ;
Van Broeckhoven, Christine (University of Antwerp) ;
Tanzi, Rudolph E. (Massachusetts General Hospital (Boston)) ;
ten Kate, Mara (Amsterdam UMC. University Medical Center) ;
Wittig, Michael (Christian-Albrechts-University of Kiel. Institute of Clinical Molecular Biology) ;
Franke, Andre (Christian-Albrechts-University of Kiel. Institute of Clinical Molecular Biology) ;
Lill, Christina M. (Imperial College. School of Public Health) ;
Barkhof, Frederik (University College London. Institutes of Neurology and Healthcare Engineering) ;
Lovestone, Simon (University of Oxford. Department of Psychiatry) ;
Streffer, Johannes (Translational Medicine Neuroscience. UCB Biopharma SPRL. Braine l'Alleud) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit). UK Dementia Research Institute) ;
Visser, Pieter J. (Karolinska Instutet. Department of Neurobiology) ;
Bertram, Lars (University of Oslo. Department of Psychology)
Introduction: Neurofilament light (NfL), chitinase-3-like protein 1 (YKL-40), and neurogranin (Ng) are biomarkers for Alzheimer's disease (AD) to monitor axonal damage, astroglial activation, and synaptic degeneration, respectively. [...]
2021 - 10.1002/alz.12330
Alzheimer's & Dementia, Vol. 17 Núm. 10 (october 2021) , p. 1628-1640
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