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Articles 62 records found  beginprevious21 - 30nextend  jump to record: Search took 0.01 seconds. 
21.
16 p, 1.0 MB The role of macroh2a histone variants in cancer / Hsu, Chen-Jen (Internal Medicine C. Greifswald University Medicine) ; Meers, Oliver (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Heidel, Florian H. (Leibniz Institute on Aging. Fritz-Lipmann Institute)
The epigenome regulates gene expression and provides a molecular memory of cellular events. A growing body of evidence has highlighted the importance of epigenetic regulation in physiological tissue homeostasis and malignant transformation. [...]
2021 - 10.3390/cancers13123003
Cancers, Vol. 13 Núm. 12 (february 2021) , p. 3003  
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22.
18 p, 1.5 MB Epigenetic control of infant b cell precursor acute lymphoblastic leukemia / de Barrios, Oriol (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Parra, Maribel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a highly aggressive malig-nancy, with poorer prognosis in infants than in adults. A genetic signature has been associated with this outcome but, remarkably, leukemogenesis is commonly triggered by genetic alterations of embryonic origin that involve the deregulation of chromatin remodelers. [...]
2021 - 10.3390/ijms22063127
International journal of molecular sciences, Vol. 22 Núm. 6 (march 2021) , p. 1-18  
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23.
23 p, 6.5 MB Genetic determinants of plasma low-density lipoprotein cholesterol levels : Monogenicity, polygenicity, and "missing" heritability / Martín-Campos, Jesús Maria (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Changes in plasma low-density lipoprotein cholesterol (LDL-c) levels relate to a high risk of developing some common and complex diseases. LDL-c, as a quantitative trait, is multifactorial and depends on both genetic and environmental factors. [...]
2021 - 10.3390/biomedicines9111728
Biomedicines, Vol. 9 Núm. 11 (november 2021) , p. 1728  
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24.
19 p, 3.7 MB Epigenetic landscape in the kick-and-kill therapeutic vaccine BCN02 clinical trial is associated with antiretroviral treatment interruption (ATI) outcome / Oriol-Tordera, Bruna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Esteve-Codina, Anna (Universitat Pompeu Fabra) ; Berdasco, Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Rosás-Umbert, Míriam (Aarhus University Hospital (Aarhus, Dinamarca)) ; Gonçalves, Elena (Sorbonne Université) ; Duran-Castells, Clara (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Puertas, Maria C. (CIBERINFEC) ; Tolstrup, Martin (Aarhus University Hospital (Aarhus, Dinamarca)) ; Søgaard, Ole S. (Aarhus University Hospital (Aarhus, Dinamarca)) ; Clotet Sala, Bonaventura (Institut Germans Trias i Pujol) ; Martínez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ; Hanke, Tomáš (Kumamoto University) ; Combadiere, Behazine (Sorbonne Université) ; Paredes, Roger (Institut Germans Trias i Pujol) ; Hartigan-O'Connor, Dennis (UC Davis School of Medicine(Estats Units d'Amèrica)) ; Esteller, M (Universitat de Barcelona. Departament de Ciències Fisiològiques II) ; Meulbroek, Michael (Projecte dels NOMS-Hispanosida, BCN Checkpoint (Barcelona)) ; Calle, M. Luz (Universitat de Vic) ; Sánchez, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Moltó, José (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ruiz-Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
European Commission. Horizon 2020 $a The BCN02-trial combined therapeutic vaccination with a viral latency reversing agent (romidepsin, RMD) in HIV-1-infected individuals and included a monitored antiretroviral pause (MAP) as an efficacy read-out identifying individuals with an early or late (< or > 4weeks) viral-rebound. [...]
2022 - 10.1016/j.ebiom.2022.103956
EBioMedicine, Vol. 78 (march 2022)  
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25.
14 p, 1.1 MB Ethical implications of epigenetics in the era of personalized medicine / Santaló, Josep (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Berdasco, Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
Given the increasing research activity on epigenetics to monitor human diseases and its connection with lifestyle and environmental expositions, the field of epigenetics has attracted a great deal of interest also at the ethical and societal level. [...]
2022 - 10.1186/s13148-022-01263-1
Clinical Epigenetics, Vol. 14 (march 2022)  
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26.
15 p, 2.1 MB AAV-mediated expression of secreted and transmembrane αKlotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice / Roig-Soriano, Joan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Griñán-Ferré, Christian (Universitat de Barcelona. Institut de Neurociències) ; Espinosa-Parrilla, J. F. (Universitat Autònoma de Barcelona) ; Abraham, Carmela R (Boston University School of Medicine) ; Bosch i Merino, Assumpció (Instituto de Salud Carlos III) ; Pallàs, Mercè (Universitat de Barcelona. Institut de Neurociències) ; Chillón Rodríguez, Miguel (Institució Catalana de Recerca i Estudis Avançats)
Senescence represents a stage in life associated with elevated incidence of morbidity and increased risk of mortality due to the accumulation of molecular alterations and tissue dysfunction, promoting a decrease in the organism's protective systems. [...]
2022 - 10.1111/acel.13581
Aging Cell, Vol. 21 (march 2022)  
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27.
29 p, 1.4 MB Lipid Metabolism and Epigenetics Crosstalk in Prostate Cancer / Pardo, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ruiz de Porras, Vicenç (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gil, Joan (Institut d'Investigació Biomèdica Sant Pau) ; Font, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Puig Domingo, Manuel (Universitat Autònoma de Barcelona. Departament de Medicina) ; Jordà, Mireia (Institut Germans Trias i Pujol)
Prostate cancer (PCa) is the most commonly diagnosed malignant neoplasm in men in the Western world. Localized low-risk PCa has an excellent prognosis thanks to effective local treatments; however, despite the incorporation of new therapeutic strategies, metastatic PCa remains incurable mainly due to disease heterogeneity and the development of resistance to therapy. [...]
2022 - 10.3390/nu14040851
Nutrients, Vol. 14 Núm. 4 (february 2022) , p. 851  
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28.
21 p, 2.7 MB Conservation of Aging and Cancer Epigenetic Signatures across Human and Mouse / Pérez, Raúl F. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Tejedor, Juan Ramón (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Santamarina-Ojeda, Pablo (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Martínez, Virginia López (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Urdinguio, Rocío G. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Villamañán, Lucía (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Candiota Silveira, Ana Paula (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sarró, N. mí Vidal (Institut d'Investigació Biomèdica de Bellvitge) ; Barradas, Marta (Metabolic Syndrome Group-BIOPROMET) ; Fernandez-Marcos, Pablo Jose (Metabolic Syndrome Group-BIOPROMET) ; Serrano, Manuel (Institució Catalana de Recerca i Estudis Avançats) ; Fernández, Agustín F (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Fraga, Mario F.. (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Aging and cancer are two interrelated processes, with aging being a major risk factor for the development of cancer. Parallel epigenetic alterations have been described for both, although differences, especially within the DNA hypomethylation scenario, have also been recently reported. [...]
2021 - 10.1093/molbev/msab112
Molecular biology and evolution, Vol. 38, Issue 8 (August 2021) , p. 3415-3435  
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29.
31 p, 3.8 MB Epigenetic Biomarkers in Cardiovascular Diseases / Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Cardiovascular diseases are the number one cause of death worldwide and greatly impact quality of life and medical costs. Enormous effort has been made in research to obtain new tools for efficient and quick diagnosis and predicting the prognosis of these diseases. [...]
2019 - 10.3389/fgene.2019.00950
Frontiers in genetics, Vol. 10 (october 2019)  
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30.
32 p, 1.4 MB Epigenetics in Breast Cancer Therapy-New Strategies and Future Nanomedicine Perspectives / Buocikova, Verona (Biomedical Research Center of the Slovak Academy of Sciences) ; Rios-Mondragon, Ivan (University of Bergen) ; Pilalis, Eleftherios (Biomedical Research Foundation of the Academy of Athens) ; Chatziioannou, Aristotelis (Biomedical Research Foundation of the Academy of Athens) ; Miklikova, Svetlana (Biomedical Research Center of the Slovak Academy of Sciences) ; Mego, Michal (Comenius University and National Cancer Institute) ; Pajuste, Karlis (Latvian Institute of Organic Synthesis) ; Rucins, Martins (Latvian Institute of Organic Synthesis) ; Yamani, Naouale El (NILU-Norwegian Institute for Air Research) ; Longhin, Eleonora Marta (NILU-Norwegian Institute for Air Research) ; Sobolev, Arkadij (Latvian Institute of Organic Synthesis) ; Gustà, Muriel F (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ; Plotniece, Aiva (Latvian Institute of Organic Synthesis) ; Dusinska, Maria (NILU-Norwegian Institute for Air Research) ; Cimpan, Mihaela Roxana (University of Bergen) ; Gabelova, Alena (Slovak Academy of Sciences) ; Smolkova, Bozena (Slovak Academy of Sciences) ; Universitat Autònoma de Barcelona
Despite advances in cancer treatment, difficult-to-treat tumor subtypes remain a challenge. New multidisciplinary approaches can help overcome current obstacles posed by tumor heterogeneity, activation and enrichment of cancer stem cells, and acquired drug resistance development. [...]
2020 - 10.3390/cancers12123622
Cancers, Vol. 12 (december 2020)  
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